Excess BMI Ups Risk of T1DM in Autoantibody-Positive Relatives

Share this content:
Excess BMI Ups Risk of T1DM in Autoantibody-Positive Relatives
Excess BMI Ups Risk of T1DM in Autoantibody-Positive Relatives

MONDAY, Feb. 20, 2017 (HealthDay News) -- For autoantibody-positive relatives of patients with type 1 diabetes, elevated body mass index (BMI) is associated with increased risk of progression to type 1 diabetes, especially for those aged younger than 12 years, according to a study published online Feb. 15 in Diabetes Care.

Christine Therese Ferrara, M.D., from the University of California in San Francisco, and colleagues studied 1,117 children in the TrialNet Pathway to Prevention cohort, which comprised autoantibody-positive relatives of patients with type 1 diabetes. A cumulative excess BMI (ceBMI) index was generated using longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile. Sex- and age-specific ceBMI thresholds were examined for type 1 diabetes risk.

The researchers found that higher ceBMI conferred significantly elevated risk of progression to type 1 diabetes. In children aged younger than 12 years, the increased diabetes risk occurred at lower ceBMI values, compared with older subjects, and in females versus males.

"Elevated BMI is associated with increased risk of diabetes progression in pediatric autoantibody-positive relatives, but the effect varies by sex and age," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

Out-of-Pocket Expenditures Down With ACA Implementation

Out-of-Pocket Expenditures Down With ACA Implementation

Reduced out-of-pocket costs seen especially for lower-income groups; mean premium costs up overall

Gynecologic Complications Up With Hysteroscopic Sterilization

Gynecologic Complications Up With Hysteroscopic Sterilization

But lower risk of surgical and medical complications versus laparoscopic sterilization

Prevalence of Cigarette Smoking 15.5 Percent in 2016

Prevalence of Cigarette Smoking 15.5 Percent in 2016

Increase in percentage of ever smokers who quit during 2005 to 2016, from 50.8 to 59 percent

is free, fast, and customized just for you!

Already a member?

Sign In Now »