Estriol Gel Aids Vaginal Health Pre, Post Genital Prolapse Sx

Share this content:
Estriol Gel Aids Vaginal Health Pre, Post Genital Prolapse Sx
Estriol Gel Aids Vaginal Health Pre, Post Genital Prolapse Sx

FRIDAY, March 31, 2017 (HealthDay News) -- For postmenopausal women undergoing surgical treatment for pelvic organ prolapse, vaginal estriol gel is associated with improvement in vaginal health, according to a study published online March 27 in Menopause.

Salvatore Caruso, M.D., from the University of Catania in Italy, and colleagues randomized women to receive daily vaginal gel containing 50 µg estriol for 12 weeks (Group A, 38 women) or no estrogen treatment (Group B, 37 women). One week after vaginal surgery, group A was re-randomized to Group A1 receiving estriol gel for 12 weeks and group A2 discontinuing treatment.

The researchers found that group A had improvement in all aspects of vaginal health before surgery versus baseline (P < 0.001). Group A1 experienced further improvement 13 weeks after surgery compared with the presurgery estriol treatment (P < 0.01), while group A2 experienced a worsening of vaginal health compared with intragroup presurgery estriol treatment (P < 0.01) and compared with intergroup surgical estriol treatment (P < 0.05). Improvement in quality of life was seen for women only after surgery, with or without estriol treatment (P < 0.01 and 0.05, respectively). There was no change in sexual function of participants on estriol before surgery; however, improvement was noted after surgery for participants on estriol and not on estriol (P < 0.001 and 0.01, respectively).

"Estriol vaginal gel (0.005 percent) administration significantly improved the vaginal health of natural postmenopausal women before and after vaginal surgery," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

USPSTF Urges BP Screening for Pre-eclampsia During Pregnancy

USPSTF Urges BP Screening for Pre-eclampsia During Pregnancy

Grade B recommendation suggests substantial net benefit for screening for pre-eclampsia

Evidence Suggests Sodium Guidelines Are Misguided

Evidence Suggests Sodium Guidelines Are Misguided

Dietary sodium intake inversely associated with systolic, diastolic blood pressure in long term

Waiting 10 Months for Colonoscopy May Raise CRC Risk

Waiting 10 Months for Colonoscopy May Raise CRC ...

After positive FIT result, colonoscopy at 10 months also tied to more advanced disease

is free, fast, and customized just for you!

Already a member?

Sign In Now »