Endometrial Microbiota May Be Linked to Success of IVF

Share this content:
Endometrial Microbiota May Be Linked to Success of IVF
Endometrial Microbiota May Be Linked to Success of IVF

THURSDAY, Dec. 15, 2016 (HealthDay News) -- The presence of a non-Lactobacillus-dominated microbiota in a receptive endometrium is associated with poor reproductive outcomes for women undergoing in vitro fertilization (IVF), according to a study published in the December issue of the American Journal of Obstetrics & Gynecology.

Inmaculada Moreno, Ph.D., from Igenomix SL in Valencia, Spain, and colleagues examined the existence of an endometrial microbiota that differs from that in the vagina and examined its impact on reproductive outcome in infertile patients undergoing IVF. The hormonal regulation of the endometrial microbiota was investigated and the reproductive impact of an altered endometrial microbiota in endometrial fluid was assessed in infertile patients undergoing IVF.

The researchers found that paired endometrial fluid and vaginal aspirate samples showed that there were different bacterial communities between the uterine cavity and the vagina of some subjects. The microbiota in the endometrial fluid was defined as a Lactobacillus-dominated microbiota or a non-Lactobacillus-dominated microbiota. The presence of a non-Lactobacillus-dominated microbiota was not hormonally regulated during acquisition of endometrial receptivity, but in a receptive endometrium it was associated with significant decreases in the rates of implantation, pregnancy, ongoing pregnancy, and live birth.

"Our results demonstrate the existence of an endometrial microbiota that is highly stable during the acquisition of endometrial receptivity," the authors write. "However, pathological modification of its profile is associated with poor reproductive outcomes for in vitro fertilization patients."

Several authors are employees of Igenomix SL and Lifesequencing SL, both of which funded the study.

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Medicare Requiring Hospitals to Post Prices Online

Medicare Requiring Hospitals to Post Prices Online

Medicare would base part of a hospital's payments on how easy it is for patients to access medical records

Restless Brain Syndrome Tied to Changes in the Brain

Restless Brain Syndrome Tied to Changes in the ...

Morphological differences seen in the primary somatosensory system

People With Opioid Use Disorder Have High Suicide Rate

People With Opioid Use Disorder Have High Suicide ...

Based on data from multiple sources, many opioid-overdose deaths seem to be suicides

is free, fast, and customized just for you!

Already a member?

Sign In Now »