Effects of APOE Gene May Be Apparent in Childhood

This article originally appeared here.
Share this content:
Effects of <i>APOE</i> Gene May Be Apparent in Childhood
Effects of APOE Gene May Be Apparent in Childhood

THURSDAY, July 14, 2016 (HealthDay News) -- Variations in the APOE gene may start to show effects on brain structure and mental acuity as early as preschool, according to a study published online July 13 in Neurology.

The findings were based on brain magnetic resonance imaging of 1,187 healthy children and teenagers. Overall, 62 percent carried two copies of ε3, while around one-quarter carried at least one copy of ε4. Less than 2 percent had two ε4 variants.

The investigators found that children with one or two copies of ε4 typically differed from other children in some measures of brain structure. Similarly, young children with two copies of ε4, or one ε4 and one ε2, tended to do worse on tests of memory, cognition, and attention, at least until age 8 or 10.

"Our findings validated and extended prior smaller studies that showed altered brain development in APOE ε4-carrier children. The ε4ε4 and ε2ε4 genotypes may negatively influence brain development and brain aging at the extremes of age," the authors write. "Studying APOE ε polymorphisms in young children may provide the earliest indicators for individuals who might benefit from early interventions or preventive measures for future brain injuries and dementia."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Dermatography Helps Lessen Appearance of Surgical Scars

Dermatography Helps Lessen Appearance of Surgical Scars

Pigments can restore more natural skin appearance that patients are happy with

Drug-Resistant Bacteria Live in America's Water Systems

Drug-Resistant Bacteria Live in America's Water Systems

Bacteria found in plumbing may sicken thousands each year

Deep Brain Stimulation May Improve TBI Symptoms

Deep Brain Stimulation May Improve TBI Symptoms

Deep brain stimulation appears to boost function and quality of life

is free, fast, and customized just for you!

Already a member?

Sign In Now »