Early Study Results Promising for Genital Herpes Vaccine

Share this content:
Early Study Results Promising for Genital Herpes Vaccine
Early Study Results Promising for Genital Herpes Vaccine

FRIDAY, Jan. 20, 2017 (HealthDay News) -- A new vaccine for herpes simplex virus type 2 could be nearing human clinical trials, according to research published online Jan. 19 in PLOS Pathogens.

The new trivalent vaccine targets three different parts of the virus, shutting down its ability to enter cells and to evade detection by the immune system, senior author Harvey Friedman, M.D., a professor with the University of Pennsylvania School of Medicine's Institute for Immunology in Philadelphia, told HealthDay. The new vaccine induces an immune response that produces three antibodies targeting different aspects of the genital herpes virus. Two of the antibodies prevent the virus from blocking the immune system, while the third prevents the virus from entering cells, the researchers said.

In lab studies, the vaccine proved 98 percent effective in protecting guinea pigs against genital herpes infection, Friedman and his colleagues reported. The vaccine also promoted an immune response in monkeys, increasing the levels of antibodies targeting the virus.

"In essence, we're stimulating the immune system to attack the virus and at the same time preventing the virus from using some of the tools it has to thwart that immune attack," Friedman said. Friedman pointed out that incorporating two different attacks into a single vaccine is a "novel strategy" that may revolutionize the field. "It may be a new era of vaccines," Friedman added. "This could open up the field to other viruses that are using evasion strategies that are different, but the same concepts could be applied."

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Low-Dose Hyaluronidase Can Remove Hyaluronic Acid Fillers

Low-Dose Hyaluronidase Can Remove Hyaluronic Acid Fillers

Greater resolution of nodules with hyaluronidase versus saline; more rapid resolution with higher doses

Improvement in Race-Based Disparities in Years of Life Lost

Improvement in Race-Based Disparities in Years of Life ...

Decline in race-based disparities in years of life lost seen in the United States from 1990 to 2014

Drug-Related Endocarditis Cases Up From 2007 to 2015

Drug-Related Endocarditis Cases Up From 2007 to 2015

Increase in endocarditis over nine-year study period mirrored increase in concomitant mixed drug use

is free, fast, and customized just for you!

Already a member?

Sign In Now »