Early Research Proving Hopeful for Melanoma Vaccine

This article originally appeared here.
Share this content:
Early Research Proving Hopeful for Melanoma Vaccine
Early Research Proving Hopeful for Melanoma Vaccine

(HealthDay News) -- A highly personalized vaccine can spur an immune response in people with advanced melanoma, according to a study published online April 2 in Science.

Beatriz Carreno, Ph.D., of the Washington University School of Medicine in St. Louis, and colleagues analyzed tumor samples and healthy tissue from three patients who'd been treated for stage 3 melanoma. Because of the many genetic mutations, the researchers had to first study each patient's cancer to zero in on seven mutated proteins most likely to be recognized by the immune system as foreign. From there, they engineered a personal vaccine for each patient.

Once the patients were vaccinated, the researchers took blood samples from them every week for about four months. What they found, Carreno told HealthDay, suggested that the vaccine had an effect on the immune system, boosting the number and diversity of T cells that were targeted toward their tumor mutations.

Next up is a phase I clinical trial, which will look at the safety and efficacy of the vaccine in six patients, according to Carreno's team. If the vaccine does prove effective, Carreno said the same approach could potentially be used against other cancers that typically have a high number of mutated proteins -- including lung and bladder cancers, and certain colon cancers.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

CDC: No Change in Level of Uninsured in U.S. in 2017

CDC: No Change in Level of Uninsured in ...

Five percent of children uninsured in 2017, 41.3 and 55.0 percent had public and private coverage

Age-Related Racial Disparity Examined in Childhood Suicide

Age-Related Racial Disparity Examined in Childhood Suicide

Significantly higher incidence of suicide for black children aged 5 to 12; lower rate for black teens

Moral Distress for Docs Providing Emergency-Only Hemodialysis

Moral Distress for Docs Providing Emergency-Only Hemodialysis

Docs describe burnout and emotional exhaustion; moral distress at seeing suffering and injustice

is free, fast, and customized just for you!

Already a member?

Sign In Now »