Early Intensification of Tx Speeds Attainment of A1C Goals

Share this content:
Early Intensification of Tx Speeds Attainment of A1C Goals
Early Intensification of Tx Speeds Attainment of A1C Goals

WEDNESDAY, Aug. 17, 2016 (HealthDay News) -- For patients newly diagnosed with type 2 diabetes, early intensification of therapy after metformin failure is associated with more rapid attainment of hemoglobin A1c (A1C) goals, according to a study published online Aug. 12 in Diabetes Care.

Kevin M. Pantalone, D.O., from the Cleveland Clinic, and colleagues identified patients with newly diagnosed type 2 diabetes who failed to reach the A1C goal after three months of metformin monotherapy. The authors compared the time to A1C goal attainment in patients who received early intensification of therapy (within six months of metformin failure) or late intensification. The analysis was performed in 1,168, 679, and 429 patients for A1C goals of 7, 7.5, and 8 percent, respectively.

The researchers found that when poor glycemic control was defined as A1C >7.0, >7.5, and >8.0 percent, treatment was intensified early in 62, 69, and 72 percent of patients, respectively. The higher the A1C category, the greater the probability was of undergoing an early intensification. Among patients who received early intensification, time to A1C goal attainment was shorter, regardless of the A1C goal (all P < 0.05).

"A substantial number of patients with newly diagnosed type 2 diabetes fail to undergo intensification of therapy within six months of metformin monotherapy failure," the authors write. "Early intervention in patients when metformin monotherapy failed resulted in more rapid attainment of A1C goals."

Several authors disclosed financial ties to biopharmaceutical companies, including Merck, which funded the study.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

NAFLD Linked to Smaller Total Cerebral Brain Volume

NAFLD Linked to Smaller Total Cerebral Brain Volume

Significant correlation even after adjustment for all covariates, including age, sex, alcohol consumption

Salivary miRNAs Can ID Duration of Concussion Symptoms

Salivary miRNAs Can ID Duration of Concussion Symptoms

Pediatric patients with prolonged symptoms were accurately identified by levels of five miRNAs

Treatment Trajectories Vary for Children With Depression

Treatment Trajectories Vary for Children With Depression

Most common class got psychotherapy monotherapy, and had lowest incidence of attempted suicide

is free, fast, and customized just for you!

Already a member?

Sign In Now »