Early Insulin Initiation Beneficial in Seniors With T2DM

This article originally appeared here.
Share this content:
Early Insulin Initiation Beneficial in Seniors With T2DM
Early Insulin Initiation Beneficial in Seniors With T2DM

(HealthDay News) -- For older Medicare beneficiaries with type 2 diabetes mellitus (T2DM), early insulin initiation offers clinical benefit, according to a study published online May 8 in the Journal of the American Geriatrics Society.

Rituparna Bhattacharya, Ph.D., from West Virginia University in Morgantown, and colleagues examined the impact of the timing of insulin initiation in a cohort of older (≥65 years) Medicare beneficiaries with T2DM. Participants were classified according to the number of oral antidiabetes drugs (OADs) that they had taken before initiation of insulin: one (early insulin initiators), two, or three or more (delayed insulin initiators). Data were included for 14,669 individuals; baseline and one-year follow-up hemoglobin A1c (HbA1c) levels were available for 27.5 percent of participants.

The researchers found that for the groups with one, two, and three or more OADs, the unadjusted reduction in HbA1c at follow-up was 0.9 ± 3.7 percent, 0.7 ± 2.4 percent, and 0.5 ± 3.6 percent, respectively. Early insulin initiation correlated with significantly greater decline in HbA1c (0.4 percent; P < 0.001) and increased odds of achieving HbA1c less than 8.0 percent (adjusted odds ratio, 1.30). There were no significant differences in total costs or hypoglycemia events for early versus delayed initiators (P = 0.32).

"These findings fill a crucial knowledge gap regarding the association between early insulin initiation and clinical and economic outcomes in older adults with T2DM," the authors write.

Two authors are employees of Sanofi, and one is a shareholder; the study was funded by Sanofi.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists can suggest adjustments for meds taken several times per day, those affected by food intake

AUA: Many Have Unused Opioids After Urologic Procedures

AUA: Many Have Unused Opioids After Urologic Procedures

Patients use just over half of initial prescription; highest percentage of unused meds for cystectomy

Over Half of Young Adult Smoke Volume Exposure From Hookahs

Over Half of Young Adult Smoke Volume Exposure ...

Toxicant exposure to tar, carbon monoxide, nicotine lower, but still substantial, compared to cigarettes

is free, fast, and customized just for you!

Already a member?

Sign In Now »