Early Age-Related Macular Degeneration Linked to High HDL

Share this content:
Early Age-Related Macular Degeneration Linked to High HDL
Early Age-Related Macular Degeneration Linked to High HDL

FRIDAY, March 30, 2018 (HealthDay News) -- There is a higher risk for early age-related macular degeneration (AMD) in individuals with high plasma high-density lipoprotein cholesterol levels, according to a study published online March 29 in JAMA Ophthalmology.

Valentine Saunier, M.D., from the Université de Bordeaux in France, and colleagues describe the incidence and associated risk factors of AMD among 659 residents of Bordeaux in France who were aged 73 years or older at baseline.

The researchers found that the incidence rates of early and advanced AMD were 79.9 and 18.6 per 1,000 person-years, respectively, corresponding to five-years risks of 32.9 and 8.9 percent. The incidence of advanced AMD per 1,000 eye-years was 1.5, 42.4, and 85.1 in those without any AMD at baseline, with early AMD1, and with early AMD2, respectively. Progression from early to advanced AMD was associated with AMD grade in the fellow eye (hazard ratio [HR] according to grade, 13.0 to 22.5), having smoked at least 20 pack-years (HR, 3.0), and complement factor H Y402H genotype (CC genotype: HR, 2.3). There was a correlation for incidence of early AMD with early AMD in the fellow eye (early AMD 1 and 2: HRs, 2.6 and 5.6, respectively) and high plasma high-density lipoprotein cholesterol levels (HR, 1.2).

"This study suggests a high risk for incident early AMD in individuals with high plasma high-density lipoprotein cholesterol levels," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

CDC: Birth Rate for 10- to-14-Year-Olds at Record Low in 2016

CDC: Birth Rate for 10- to-14-Year-Olds at Record ...

Reduction in birth rates for all race and Hispanic origin groups; largest decline in non-Hispanic blacks

Lonafarnib May Lower Mortality in Hutchinson-Gilford Progeria

Lonafarnib May Lower Mortality in Hutchinson-Gilford Progeria

Lower mortality seen with lonafarnib monotherapy after 2.2 years compared with no treatment

About 40 Percent of Men Report Experiencing Weight Stigma

About 40 Percent of Men Report Experiencing Weight ...

Experience of weight stigma associated with increased odds of underweight or obesity

is free, fast, and customized just for you!

Already a member?

Sign In Now »