Duration of Estrogen Rx May Be Important Factor in Renal Health

Share this content:
Duration of Estrogen Rx May Be Important Factor in Renal Health
Duration of Estrogen Rx May Be Important Factor in Renal Health

MONDAY, Dec. 12, 2016 (HealthDay News) -- For midlife ovariectomized Long Evans rats, long-term estradiol (E2) treatment exerts detrimental effects on kidney health, despite lowering blood pressure, while short-term E2 lowers blood pressure and reduces renal damage, according to an experimental study published online Nov. 9 in American Journal of Physiology-Renal Physiology.

Margaret A. Zimmerman, Ph.D., from Tulane University in New Orleans, and colleagues ovariectomized female Long Evans retired breeders at age 11 months and randomized them into three groups: 80 days vehicle (Veh>Veh), 40 days E2 + 40 days vehicle (E2>Veh), and 80 days E2 (E2>E2).

The researchers found that the E2>Veh and E2>E2 groups had lower systolic blood pressure and enhanced mesenteric relaxation in response to estrogen receptor α stimulation compared with Veh>Veh. E2>E2 induced renal and cardiac hypertrophy, reduced glomerular filtration, and increased proteinuria in spite of reduced blood pressure. Significantly fewer tubular casts were seen in kidneys from E2>Veh rats than in the other groups.

"These findings highlight that the duration of hormone therapy may be an important factor for renal health in aging postmenopausal women," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »