Duration of Estrogen Deficiency Linked to Fibrosis Risk in NAFLD

This article originally appeared here.
Share this content:
Duration of Estrogen Deficiency Linked to Fibrosis Risk in NAFLD
Duration of Estrogen Deficiency Linked to Fibrosis Risk in NAFLD

FRIDAY, March 18, 2016 (HealthDay News) -- For postmenopausal women with nonalcoholic fatty liver disease (NAFLD), longer duration of estrogen deficiency is associated with increased odds of having more severe fibrosis, according to a study published online Feb. 26 in Hepatology.

Jagpal Singh Klair, M.D., from the University of Arkansas for Medical Sciences in Little Rock, and colleagues examined the correlations of age at menopause and time from menopause with fibrosis severity in postmenopausal women with NAFLD. Data were included for 488 postmenopausal women with histologic diagnosis of NAFLD.

The researchers found that women with premature menopause (age at menopause of <40 years) were younger at study enrollment and more frequently used hormone replacement therapy. Premature menopause correlated with increased likelihood of having more severe fibrosis after adjustment for multiple confounding variables, including age at study enrollment, race, and hormone replacement therapy (adjusted cumulative odds ratio, 1.9; P = 0.001). Time from menopause correlated directly with increased likelihood of having more severe fibrosis (adjusted cumulative odds ratio for five-year unit, 1.2; P = 0.002).

"Duration of estrogen deficiency in postmenopausal state confers fibrosis risk among post-menopausal women with NAFLD," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Dermatography Helps Lessen Appearance of Surgical Scars

Dermatography Helps Lessen Appearance of Surgical Scars

Pigments can restore more natural skin appearance that patients are happy with

Drug-Resistant Bacteria Live in America's Water Systems

Drug-Resistant Bacteria Live in America's Water Systems

Bacteria found in plumbing may sicken thousands each year

Deep Brain Stimulation May Improve TBI Symptoms

Deep Brain Stimulation May Improve TBI Symptoms

Deep brain stimulation appears to boost function and quality of life

is free, fast, and customized just for you!

Already a member?

Sign In Now »