Drug Shows Promise for Genetic Proopiomelanocortin Deficiency

Share this content:
Drug Shows Promise for Genetic Proopiomelanocortin Deficiency
Drug Shows Promise for Genetic Proopiomelanocortin Deficiency

THURSDAY, July 21, 2016 (HealthDay News) -- An experimental drug spurred substantial weight loss in patients with proopiomelanocortin (POMC) deficiency, according to a study published in the July 21 issue of the New England Journal of Medicine.

In the new study, researchers in France and Germany tested an experimental compound called setmelanotide in two adults with POMC deficiency. The drug is being developed by a Boston biotech firm called Rhythm Pharmaceuticals, to treat rare genetic causes of obesity. According to the company, setmelanotide activates a receptor on cells that would normally be turned on by melanocyte-stimulating hormone, derived from POMC.

The patients in this study -- both women in their 20s -- were severely obese, weighing close to 350 pounds. After about 10 months of daily setmelanotide injections, one patient had lost 112 pounds. The other lost 45 pounds over three months of treatment. The first patient initially had her treatment stopped after three months. She immediately became excessively hungry and began to regain the weight, lead researcher Peter Kuhnen, M.D., of the Charite-Medical University of Berlin, told HealthDay. Once the patient went back on the drug, her hunger eased and her weight loss continued.

"For this reason, we presume that the patients will need to take the drug indefinitely," Kuhnen said.

One author disclosed financial ties to Rhythm Pharmaceuticals, which provided the study medication and regulatory support.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »