Drug, Herb Interactions Frequent for Cancer Patients

This article originally appeared here.
Share this content:
Drug, Herb Interactions Frequent for Cancer Patients
Drug, Herb Interactions Frequent for Cancer Patients

FRIDAY, June 23, 2017 (HealthDay News) -- Patients with cancer frequently have herb-drug interactions (HDI) and drug-drug interactions (DDI), some of which have clinical consequences, according to research published online June 19 in the Journal of Oncology Practice.

Allan Ramos-Esquivel, M.D., from Hospital San Juan de Dios in San José Costa Rica, and colleagues administered a questionnaire to patients starting a new anticancer therapy to identify concomitant use of any over-the-counter drug or herbal supplement. The authors examined clinically relevant DDIs and HDIs among 149 patients. If the clinical pharmacist recognized a potentially clinically relevant DDI, notification was sent to the prescribing oncologist.

The researchers identified 36 potentially clinically relevant DDIs in 26 patients (17.4 percent); all DDIs led to modifications in therapy. At the time of pharmacist notification, 2.7 percent of patients had experienced clinical consequences from DDIs. Overall, 84 patients (56.4 percent) reported concurrent herbal supplement use and there were 122 possible HDIs. There was an independent association for concomitant use of at least two drugs with high risk of a clinically significant DDI (odds ratio, 2.53).

"Potentially clinically relevant DDIs and possible HDIs were frequently detected in this prospective study," the authors write. "A multidisciplinary approach is required to identify and avoid potentially harmful combinations with anticancer therapy."

One author disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

NAFLD Linked to Smaller Total Cerebral Brain Volume

NAFLD Linked to Smaller Total Cerebral Brain Volume

Significant correlation even after adjustment for all covariates, including age, sex, alcohol consumption

Salivary miRNAs Can ID Duration of Concussion Symptoms

Salivary miRNAs Can ID Duration of Concussion Symptoms

Pediatric patients with prolonged symptoms were accurately identified by levels of five miRNAs

Treatment Trajectories Vary for Children With Depression

Treatment Trajectories Vary for Children With Depression

Most common class got psychotherapy monotherapy, and had lowest incidence of attempted suicide

is free, fast, and customized just for you!

Already a member?

Sign In Now »