Drug Combo May Help Combat Hearing Loss

This article originally appeared here.
Share this content:
Drug Combo May Help Combat Hearing Loss
Drug Combo May Help Combat Hearing Loss

THURSDAY, Feb. 23, 2017 (HealthDay News) -- In response to stimulation, mammalian Lgr5+ cochlear hair cells undergo clonal expansion, a discovery that may help combat hearing loss, according to a study published in the Feb. 21 issue of Cell Reports.

Noting that death of cochlear hair cells is a cause of hearing loss in a high percentage of the population, Will J. McLean, Ph.D., from Harvard Medical School in Boston, and colleagues used a small-molecule approach to obtain large numbers of cochlear hair cells.

The researchers observed significant expansion (>2,000-fold) of cochlear supporting cells expressing and maintaining the epithelial stem cell marker Lgr5, in response to stimulation of Wnt signaling by a GSK3β inhibitor and transcriptional activation by a histone deacetylase inhibitor. Cells expressing Lgr5 differentiate into hair cells with high yield. Over 11,500 hair cells were obtained from a single mouse cochlea, compared with fewer than 200 hair cells in the absence of induction. Bundles and molecular machinery for transduction, synapse formation, and specialized hair cell activity were found in the newly generated hair cells.

"Targeting supporting cells capable of proliferation and cochlear hair cell replacement could lead to the discovery of hearing loss treatments," the authors write.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

High Success Rates for Mitral Valve Repair With Robotic Surgery

High Success Rates for Mitral Valve Repair With ...

Minimally invasive surgery linked to fewer discharges to facility, one day less in hospital vs conservative sx

Tattoo-Linked Complications ID'd in Immunosuppressed Female

Tattoo-Linked Complications ID'd in Immunosuppressed Female

Inflammatory myopathy identified in woman with cystic fibrosis on long-term immunosuppressants

Rates of Cardiac Stress Testing Down but Still Higher in CKD

Rates of Cardiac Stress Testing Down but Still ...

Decline in rates of cardiac stress testing in Medicare beneficiaries aged ≥66 years from 2008 to 2012

is free, fast, and customized just for you!




Already a member?

Sign In Now »