Dose-Linked Pulmonary Complications After FFP Infusion

This article originally appeared here.
Share this content:
Dose-Linked Pulmonary Complications After FFP Infusion
Dose-Linked Pulmonary Complications After FFP Infusion

TUESDAY, Dec. 15, 2015 (HealthDay News) -- About 20 percent of patients administered fresh frozen plasma (FFP) to reverse warfarin anticoagulation develop pulmonary complications, with highest risk seen with more than three units of FFP, according to a study published online Dec. 8 in the Journal of Thrombosis and Haemostasis.

Ariela Marshall, M.D., from the Mayo Clinic in Rochester, Minn., and colleagues examined the incidence and dose relationship of pulmonary complications, including transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI), in 251 patients receiving FFP for warfarin reversal.

The researchers found that 20 percent of patients developed pulmonary complications, including 12 percent TACO, 1 percent TRALI, and 7 percent pulmonary edema that did not meet the criteria for TACO. Patients who received more than three units of FFP had pulmonary complications significantly more frequently (34.0 versus 15.6 percent; P = 0.006). Only the risk of TACO was significant on stratification by subtype of complication (28.3 versus 7.6 percent; P = 0.0002). After controlling for age, sex, initial systolic blood pressure, and intravenous fluids given in the emergency department, receipt of more than three units of FFP remained significantly associated with pulmonary complications (odds ratio, 2.49; P = 0.01).

"Almost 20 percent of patients who received FFP for warfarin reversal developed pulmonary complications, primarily TACO, and this risk increased with greater than three units of FFP," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Surveillance Frequency Doesn't Cut Mortality in Colorectal Cancer

Surveillance Frequency Doesn't Cut Mortality in Colorectal Cancer

And, intensity of imaging surveillance not linked to time to detection of colorectal cancer recurrence

Procalcitonin Assay Doesn't Cut Antibiotic Use in Lower RTI

Procalcitonin Assay Doesn't Cut Antibiotic Use in Lower ...

Provision of assay doesn't result in less antibiotic use for suspected lower respiratory tract infection

Preventing Child Maltreatment Not Yet Feasible in Primary Care

Preventing Child Maltreatment Not Yet Feasible in Primary ...

USPSTF says evidence inadequate for primary care interventions to prevent child maltreatment

is free, fast, and customized just for you!

Already a member?

Sign In Now »