Digestive Byproduct of Meat Linked to Mortality Risk in PAD

Share this content:
Digestive Byproduct of Meat Linked to Mortality Risk in PAD
Digestive Byproduct of Meat Linked to Mortality Risk in PAD

THURSDAY, Oct. 20, 2016 (HealthDay News) -- Patients with peripheral artery disease (PAD) who also have high levels of trimethylamine N-oxide (TMAO), a by-product of meat consumption, may have a higher risk of dying within five years, compared with those with the lowest levels, according to a study published online Oct. 19 in the Journal of the American Heart Association.

W.H. Wilson Tang, M.D., a professor in medicine at the Cleveland Clinic, and colleagues studied the relationship between PAD and TMAO in 821 men and women seen at the Cleveland Clinic. The average age of the study volunteers was 66 years. All were screened for PAD and levels of TMAO. The study participants' health was then followed for five years between 2001 and 2007.

After adjusting the data to account for traditional risk factors, inflammatory biomarkers, and history of coronary artery disease, the researchers found that patients with the highest levels of TMAO had double the odds of dying during a five-year period than those with the lowest levels of TMAO (adjusted hazard ratio, 2.06).

"TMAO, a pro-atherogenic metabolite formed by gut microbes, predicts long-term adverse event risk and incremental prognostic value in patients with PAD," the authors write. "These findings point to the potential for TMAO to help improve selection of high-risk PAD patients with or without significant coronary artery disease, who likely need more aggressive and specific dietary and pharmacologic therapy."

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

24-Hour Primary Care Clinics Would Improve Continuity of Care

24-Hour Primary Care Clinics Would Improve Continuity of ...

Model involving multiple doctors working shifts in their own clinic offers many benefits

Repeat BP Reading Needed in Children With Initial High Result

Repeat BP Reading Needed in Children With Initial ...

Based on initial reading, more than half of children would have incorrect classification

Brochure Can Improve Opioid Disposal Rates After Surgery

Brochure Can Improve Opioid Disposal Rates After Surgery

Patients more likely to dispose of unused opioids after getting information and recommendations

is free, fast, and customized just for you!

Already a member?

Sign In Now »