Diagnostic Potential for Blood-Based NfL in Parkinson's Disease

This article originally appeared here.
Share this content:
Diagnostic Potential for Blood-Based NfL in Parkinson's Disease
Diagnostic Potential for Blood-Based NfL in Parkinson's Disease

WEDNESDAY, Feb. 8, 2017 (HealthDay News) -- Measuring blood neurofilament light chain (NfL) levels may help distinguish Parkinson's disease (PD) from atypical parkinsonian disorders (APD), according to a study published online Feb. 8 in Neurology.

For the study, Oskar Hansson, M.D., Ph.D., a researcher at Lund University in Sweden, and colleagues included 504 individuals from three independent prospective cohorts. Blood NfL levels were measured utilizing an ultrasensitive single molecule array method.

The team found strong correlations between blood and cerebrospinal fluid concentrations of NfL. Compared to patients with PD and healthy controls, blood NfL was increased in all APD groups. In one cohort, blood NfL was found to accurately distinguish PD from APD (area under the curve, 0.91), with similar results seen in the London and early disease cohorts (area under the curve, 0.85 and 0.81, respectively).

"Quantification of blood NfL concentration can be used to distinguish PD from APD," the authors write. "Blood-based NfL might consequently be included in the diagnostic workup of patients with parkinsonian symptoms in both primary care and specialized clinics."

Several authors disclosed financial ties to pharmaceutical and diagnostic companies, including UmanDiagnostics.

Abstract
Full Text
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

NAFLD Linked to Smaller Total Cerebral Brain Volume

NAFLD Linked to Smaller Total Cerebral Brain Volume

Significant correlation even after adjustment for all covariates, including age, sex, alcohol consumption

Salivary miRNAs Can ID Duration of Concussion Symptoms

Salivary miRNAs Can ID Duration of Concussion Symptoms

Pediatric patients with prolonged symptoms were accurately identified by levels of five miRNAs

Treatment Trajectories Vary for Children With Depression

Treatment Trajectories Vary for Children With Depression

Most common class got psychotherapy monotherapy, and had lowest incidence of attempted suicide

is free, fast, and customized just for you!

Already a member?

Sign In Now »