Diabetes Symptoms Appear to Spread Via Prion-Like Mechanism

Share this content:
Diabetes Symptoms Appear to Spread Via Prion-Like Mechanism
Diabetes Symptoms Appear to Spread Via Prion-Like Mechanism

TUESDAY, Aug. 1, 2017 (HealthDay News) -- Amyloid polypeptide (IAPP) deposits in the pancreas may lead scientists to a better understanding of type 2 diabetes, according to research published online Aug. 1 in the Journal of Experimental Medicine.

IAPP collects in the pancreas in patients with type 2 diabetes, but whether these deposits cause the disease or appear after the disease begins hasn't been clear. Researchers from McGovern Medical School at the University of Texas Health Science Center in Houston injected mice with this protein to try to better define its role in type 2 diabetes.

The investigators found that when the mice received this protein, the animals developed symptoms of type 2 diabetes, such as the death of insulin-producing cells in the pancreas and high blood glucose levels. The study team also injected the protein into pancreatic tissue from healthy human donors and found that IAPP collected in the pancreatic tissue.

"Almost all patients with type 2 diabetes have these protein [deposits], but we don't know if it's a disease pathway or a correlate," study author Claudio Soto, Ph.D., a professor of neurology at McGovern, told HealthDay. Soto theorized that when insulin production increases, so does IAPP, and the excess IAPP collects in the pancreas. The study team said that a small number of these protein deposits can then encourage the misfolding of additional proteins. Eventually, large deposits can form that damage the beta cells. Soto says more research is needed.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

NTproBNP Levels Are Significantly Lower in Blacks

NTproBNP Levels Are Significantly Lower in Blacks

Higher NTproBNP levels linked to increased risk of death; this association did not differ by race

Data May Weigh on Pros/Cons of Expanded Care Optometry

Data May Weigh on Pros/Cons of Expanded Care ...

Majority of residents in Kentucky, Oklahoma, New Mexico live within 30 minutes of ophthalmologist

Gaps Seen Between Hearing Loss, Receipt of Medical Evaluation, Tx

Gaps Seen Between Hearing Loss, Receipt of Medical ...

About 20.6 percent of those with hearing less than excellent/good had visited doctor for hearing issues

is free, fast, and customized just for you!

Already a member?

Sign In Now »