DHEA Suppository May Ease Menopausal Vaginal Symptoms

Share this content:
DHEA Suppository May Ease Menopausal Vaginal Symptoms
DHEA Suppository May Ease Menopausal Vaginal Symptoms

WEDNESDAY, Jan. 6, 2016 (HealthDay News) -- For postmenopausal women, suppositories containing the hormone dehydroepiandrosterone (DHEA) may reduce vaginal dryness, discomfort, and pain during sex without raising overall estrogen levels, according to research published online Dec. 28 in Menopause.

"Although this medication is considered 'hormonal,' the mechanism appears to be primarily local with minimal side effects beyond vaginal discharge from the suppository," JoAnn Pinkerton, M.D., executive director of the North American Menopause Society, said in a Society news release.

In this phase 3 clinical trial, 325 women who used the DHEA suppository daily saw significant improvements in vaginal dryness after 12 weeks, compared to 157 women using a placebo.

"Its action seems to be entirely within [vaginal] cells, and no significant amount of sex hormone gets released into the circulation," Pinkerton said. "That means that intravaginal DHEA avoids the raised hormone levels that might stimulate breast tissue or the lining of the uterus, which are concerns for women at risk of estrogen-sensitive cancers, or cancer recurrence, in these organs."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters




More in Home

AAP: Congress Urged to Act to Prevent Firearm Deaths

AAP: Congress Urged to Act to Prevent Firearm ...

Following latest shooting, pediatricians join call for action to be taken to address firearm deaths, injury

Lung Cancer Incidence Higher for Young Women Than Young Men

Lung Cancer Incidence Higher for Young Women Than ...

Crossover in sex-specific rates among U.S. non-Hispanic whites born since 1965

E-Cigarette Flavoring Agent May Impair Airway Defense System

E-Cigarette Flavoring Agent May Impair Airway Defense System

Flavoring commonly used in e-cigarettes suppresses cilia beat frequency, lasting for 60 minutes