Dexmedetomidine Found to Prevent Delirium in Critically Ill

Share this content:
Dexmedetomidine Found to Prevent Delirium in Critically Ill
Dexmedetomidine Found to Prevent Delirium in Critically Ill

MONDAY, March 5, 2018 (HealthDay News) -- Low-dose dexmedetomidine significantly reduces delirium in critically ill adults, according to a study published online March 2 in the American Journal of Respiratory and Critical Care Medicine.

Yoanna Skrobik, M.D., from McGill University in Montreal, and colleagues randomized 100 delirium-free, critically ill adults receiving sedatives to receive nocturnal intravenous dexmedetomidine (0.2 mcg/kg/min) or placebo until discharge from the intensive care unit (ICU). Effect on delirium and sleep was assessed.

The researchers found that nocturnal dexmedetomidine was associated with a greater proportion of patients who remained delirium-free during the ICU stay (relative risk, 0.44; P = 0.006). However, the average Leeds Sleep Evaluation Questionnaire score was similar between the two groups. The groups also had similar incidence of hypotension, bradycardia, or both.

"To our knowledge, this study, that suggests that the nocturnal administration of low-dose dexmedetomidine significantly reduces delirium without increasing adverse events, is the first to describe an effective pharmacologic delirium prevention intervention in critically ill adults," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Greater Satisfaction With Autologous Breast Reconstruction

Greater Satisfaction With Autologous Breast Reconstruction

And, likelihood of complications up for autologous reconstruction versus expander-implant technique

No Causal Effect of 25(OH)D on Gestational HTN, Preeclampsia

No Causal Effect of 25(OH)D on Gestational HTN, ...

No significant correlations identified in one-sample or two-sample mendelian randomization analyses

Valuing Gluten-Free Food Tied to Better Dietary Intake

Valuing Gluten-Free Food Tied to Better Dietary Intake

But young adults who do so also more likely to engage in unhealthy weight control behaviors

is free, fast, and customized just for you!




Already a member?

Sign In Now »