Dexamethasone No Help in HIV-Linked Cryptococcal Meningitis

Share this content:
Dexamethasone No Help in HIV-Linked Cryptococcal Meningitis
Dexamethasone No Help in HIV-Linked Cryptococcal Meningitis

FRIDAY, Feb. 12, 2016 (HealthDay News) -- For patients with HIV-associated cryptococcal meningitis, dexamethasone does not reduce mortality compared with placebo, according to a study published in the Feb. 11 issue of the New England Journal of Medicine.

Justin Beardsley, M.B., Ch.B., from the Oxford University Clinical Research Unit in the United Kingdom, and colleagues recruited adult patients with HIV-associated cryptococcal meningitis in Vietnam, Thailand, Indonesia, Laos, Uganda, and Malawi. Participants were randomized to dexamethasone or placebo for six weeks, with combination antifungal therapy with amphotericin B and fluconazole.

After enrollment of 451 patients the trial was stopped for safety reasons. The researchers found that by 10 weeks, mortality was 47 and 41 percent in the dexamethasone and placebo groups, respectively (hazard ratio in the dexamethasone group, 1.11; 95 percent confidence interval, 0.84 to 1.47); by six months, mortality was 57 and 49 percent, respectively (hazard ratio, 1.18; 95 percent confidence interval, 0.91 to 1.53). At 10 weeks, the percentage of patients with disability was higher in the dexamethasone versus the placebo group (13 and 25 percent with a prespecified good outcome, respectively; odds ratio, 0.42; 95 percent confidence interval, 0.25 to 0.69). Compared with the placebo group, the dexamethasone group more frequently had clinical adverse events (667 versus 494 events; P = 0.01)

"Dexamethasone did not reduce mortality among patients with HIV-associated cryptococcal meningitis and was associated with more adverse events and disability than was placebo," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Dermatography Helps Lessen Appearance of Surgical Scars

Dermatography Helps Lessen Appearance of Surgical Scars

Pigments can restore more natural skin appearance that patients are happy with

Drug-Resistant Bacteria Live in America's Water Systems

Drug-Resistant Bacteria Live in America's Water Systems

Bacteria found in plumbing may sicken thousands each year

Deep Brain Stimulation May Improve TBI Symptoms

Deep Brain Stimulation May Improve TBI Symptoms

Deep brain stimulation appears to boost function and quality of life

is free, fast, and customized just for you!

Already a member?

Sign In Now »