Deferred Revascularization Tied to Poor Outcomes in Diabetes

Share this content:
Deferred Revascularization Tied to Poor Outcomes in Diabetes
Deferred Revascularization Tied to Poor Outcomes in Diabetes

FRIDAY, Nov. 4, 2016 (HealthDay News) -- For patients with diabetes mellitus (DM), deferred revascularization is associated with poor medium-term outcomes, according to a study published in the Nov. 1 issue of The American Journal of Cardiology.

Mark W. Kennedy, M.B., Ch.B., from Isala Hartcentrum in Zwolle, Netherlands, and colleagues examined the safety and efficacy of deferred versus complete revascularization using a fractional flow reserve (FFR)-guided strategy in patients with DM. Data were analyzed from 294 patients who underwent FFR-guided revascularization, of whom 69.7 percent had at least one remaining FFR-negative medically treated lesion (FFR[−]MT) and 30.3 percent had only FFR-positive lesions and underwent complete revascularization (FFR[+]CR) .

The researchers found that FFR(−)MT correlated with a higher major adverse cardiovascular event (MACE) rate (44.0 versus 26.6 percent; adjusted hazard ratio, 2.01) at a mean follow-up of 32.6 months, with increased safety and efficacy end points: death/myocardial infarction (MI), rehospitalization for acute coronary syndrome, and target lesion revascularization (hazard ratios, 2.02, 2.06, and 3.38, respectively). Within the FFR(−)MT group, but not in the FFR(+)CR group, previous MI was a strong effect modifier (hazard ratio, 1.98). There was a significant interaction for MACE between FFR groups and previous MI (P = 0.03).

"In patients with DM, particularly those with previous MI, deferred revascularization is associated with poor medium-term outcomes," the authors write. "Combining FFR with imaging techniques may be required to guide our treatment strategy in these patients with high-risk, fast-progressing atherosclerosis."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

AAN: Alpha-Synuclein Levels in Tears May Help ID Parkinson's

AAN: Alpha-Synuclein Levels in Tears May Help ID ...

PD patients have significantly decreased total alpha-synuclein in tears compared with healthy controls

Younger Onset of T2DM Linked to Increased Mortality Risk

Younger Onset of T2DM Linked to Increased Mortality ...

Earlier diagnosis of T2DM tied to increased mortality, mainly driven by cardiovascular disease mortality

Menopausal Hormone Therapy Tied to Less Pronounced Kyphosis

Menopausal Hormone Therapy Tied to Less Pronounced Kyphosis

Continuous and remote past HT users had less kyphosis in minimally-, fully-adjusted models

is free, fast, and customized just for you!

Already a member?

Sign In Now »