December 2016 Briefing - Hematology & Oncology

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Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for December 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

BodyFIX Without Wrap Works for Radiotherapy Immobilization

FRIDAY, Dec. 30, 2016 (HealthDay News) -- The BodyFIX without wrap is suitable for clinical immobilization during radiotherapy, according to a study published online Dec. 20 in the Journal of Medical Radiation Sciences.

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No Effect for BUP TAP Catheter on Chronic Pain After Breast Recon

FRIDAY, Dec. 30, 2016 (HealthDay News) -- For patients undergoing autologous breast reconstruction, the incidence of chronic postsurgical pain (CPSP) does not differ for patients receiving transversus abdominis plane (TAP) catheters delivering bupivacaine or saline bolus, according to a study published online Dec. 20 in Pain Practice.

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Uric Acid May Mark Progression for Nasopharyngeal Cancer

FRIDAY, Dec. 30, 2016 (HealthDay News) -- There is a direct correlation between the pretreatment serum uric acid (SUA) level and tumor progression in patients with locally advanced nasopharyngeal carcinoma (NPC), according to a study published online Dec. 20 in Head & Neck.

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Panel of 88 SNPs Predicts Breast CA Risk in Women at High Risk

FRIDAY, Dec. 30, 2016 (HealthDay News) -- A panel of 88 single nucleotide polymorphisms (SNPs) can predict breast cancer risk, according to a study published online Dec. 28 in the Journal of Clinical Oncology.

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Incidence of Melanoma Continues to Rise in Majority of States

THURSDAY, Dec. 29, 2016 (HealthDay News) -- There is regional variation in the incidence and death rates for melanoma; and sex, sexual orientation, and race/ethnicity impact the prevalence of indoor tanning use, according to two research letters published online Dec. 28 in JAMA Dermatology.

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Iron Deficiency Anemia Ups Risk of Hearing Loss in U.S. Adults

THURSDAY, Dec. 29, 2016 (HealthDay News) -- Among U.S. adults, hearing loss is associated with iron deficiency anemia (IDA), according to a study published online Dec. 29 in JAMA Otolaryngology-Head & Neck Surgery.

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Case Report: Adoptive T-Cell Tx Shows Promise in Glioblastoma

THURSDAY, Dec. 29, 2016 (HealthDay News) -- Treatment with autologous chimeric antigen receptor (CAR)-engineered T cells targeting the tumor-associated antigen interleukin-13 receptor alpha 2 (IL13Rα2) is associated with tumor regression in recurrent multifocal glioblastoma, according to a case report published in the Dec. 29 issue of the New England Journal of Medicine.

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Selumetinib Active in Children With Neurofibromatosis Type 1

THURSDAY, Dec. 29, 2016 (HealthDay News) -- The oral selective inhibitor of MAPK kinase 1 and 2, selumetinib, is active in children with neurofibromatosis type 1 and inoperable plexiform neurofibromas, according to a study published in the Dec. 29 issue of the New England Journal of Medicine.

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Reoperation Risk for Nonpalpable Breast Lesions Higher for DCIS

THURSDAY, Dec. 29, 2016 (HealthDay News) -- For women undergoing wire-guided breast conserving surgery (BCS) for nonpalpable breast lesions, the risk of reoperation is higher for those with ductal carcinoma in situ (DCIS) than those with invasive breast cancer (IBC), according to a study published online Dec. 21 in JAMA Surgery.

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Triple-Negative Breast CA Risk Up for Blacks With Benign Breast Dz

THURSDAY, Dec. 29, 2016 (HealthDay News) -- African-American (AA) identity is associated with increased risk of triple-negative breast cancer (TNBC) among women with a prior diagnosis of benign breast disease (BBD), according to a study published online Dec. 22 in JAMA Oncology.

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Optimal Timing ID'd for Flu Shot During Three-Week Chemo Cycle

WEDNESDAY, Dec. 28, 2016 (HealthDay News) -- For adults with solid cancer undergoing three-week cytotoxic chemotherapy cycles, antibody responses are comparable for influenza vaccination on day one and 11, according to a study published online Dec. 20 in Cancer.

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Personal Health Care Spending Continues to Soar in the U.S.

TUESDAY, Dec. 27, 2016 (HealthDay News) -- From 1996 to 2013 there were considerable increases in personal health care spending in the United States, with the highest amounts for diabetes, ischemic heart disease, and low back and neck pain, according to a study published in the Dec. 27 issue of the Journal of the American Medical Association.

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Confocal Microscopy Aids Surgical Removal of Tumors From Eyelid

TUESDAY, Dec. 27, 2016 (HealthDay News) -- Imaging using fluorescence confocal microscopy (FCM) analysis in the reflectance mode and with an "en face" scanning can control tumor margins of eyelid basal cell carcinoma (BCC) to optimize surgical management, according to a study published online Dec. 19 in Clinical & Experimental Ophthalmology.

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Less Intense Surveillance OK for Some Prostate Cancer Cases

FRIDAY, Dec. 23, 2016 (HealthDay News) -- Certain patients on active surveillance for prostate cancer may be eligible for less intensive surveillance, according to a study published in the January issue of The Journal of Urology.

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Early Surgery Ups Mortality Risk for Some Endometrial CA Patients

FRIDAY, Dec. 23, 2016 (HealthDay News) -- For patients diagnosed with endometrial cancer, surgery within the first two weeks of diagnosis is associated with increased risk of mortality, according to a study published online Dec. 8 in the American Journal of Obstetrics & Gynecology.

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ASCO Updates Guideline for SNB in Early-Stage Breast Cancer

THURSDAY, Dec. 22, 2016 (HealthDay News) -- Recommendations for use of sentinel node biopsy (SNB) in early-stage breast cancer are unchanged from 2014, according to a clinical practice guideline update published online Dec. 12 in the Journal of Clinical Oncology.

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Single-Dose LMWH Can Interfere With Algorithm for DVT Diagnosis

THURSDAY, Dec. 22, 2016 (HealthDay News) -- A single dose of low-molecular-weight heparin (LMWH) given the previous day can reduce D-dimer and potentially risk non-identification of a deep vein thrombosis (DVT), according to a research letter published online Dec. 15 in the International Journal of Laboratory Hematology.

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Surgeon Input on Contralateral Prophylactic Mastectomy Needed

WEDNESDAY, Dec. 21, 2016 (HealthDay News) -- Many patients with newly diagnosed unilateral breast cancer consider contralateral prophylactic mastectomy (CPM), according to a study published online Dec. 21 in JAMA Surgery.

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Melanoma Incidence, Mortality Continue to Rise in the U.S.

WEDNESDAY, Dec. 21, 2016 (HealthDay News) -- The burden of melanoma is increasing in the United States, according to a research letter published online Dec. 21 in JAMA Dermatology.

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Radiation Dose to Head & Neck Tied to Thyroid Dysfunction Risk

WEDNESDAY, Dec. 21, 2016 (HealthDay News) -- For patients with head and neck cancer receiving radiotherapy (RT), thyroid dysfunction is a dose-related complication, with increased risk for female sex and concurrent chemotherapy, according to a study published online Dec. 1 in Head & Neck.

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Regular Aspirin Use Linked to Reduced Risk of Pancreatic CA

TUESDAY, Dec. 20, 2016 (HealthDay News) -- Regular aspirin use is associated with reduced risk of pancreatic cancer in a Chinese cohort, according to a study published online Dec. 20 in Cancer Epidemiology, Biomarkers & Prevention.

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MicroRNAs 203 and 205 Are Prognostic in Cutaneous SCC

TUESDAY, Dec. 20, 2016 (HealthDay News) -- MicroRNAs (miR-203 and miR-205) could be useful prognostic markers in cutaneous squamous cell carcinoma, with distinct expression and associations, according to a study published online Dec. 11 in the British Journal of Dermatology.

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Pathologists Vary in Suggested Therapy for Melanocytic Lesions

TUESDAY, Dec. 20, 2016 (HealthDay News) -- Pathologists have wide variability in treatment suggestions for melanocytic lesions, according to a study published in the January issue of the Journal of the American Academy of Dermatology.

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Health Care Provider Burnout Negatively Affects Quality, Safety

TUESDAY, Dec. 20, 2016 (HealthDay News) -- Health care provider burnout is negatively associated with quality and safety of health care, according to a meta-analysis published recently in the Journal of General Internal Medicine.

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FDA Grants Fast-Track Approval to Ovarian Cancer Drug

MONDAY, Dec. 19, 2016 (HealthDay News) -- The drug Rubraca (rucaparib) has been granted accelerated approval by the U.S. Food and Drug Administration to treat advanced ovarian cancer.

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No Link for Transfused Red Blood Cell Storage, Mortality

MONDAY, Dec. 19, 2016 (HealthDay News) -- For patients who received transfusions in Sweden and Denmark from 2003 to 2012, there was no correlation between the length of red blood cell (RBC) storage and mortality, according to a study published online Dec. 20 in the Annals of Internal Medicine.

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DEA Announces Critical Changes in Registration Renewal Process

MONDAY, Dec. 19, 2016 (HealthDay News) -- The Drug Enforcement Administration (DEA) has announced critical changes in its registration renewal process, according to a report published by the American Academy of Family Physicians.

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Diabetes Ups Risk of HCC, Death in Patients With Hepatitis C

MONDAY, Dec. 19, 2016 (HealthDay News) -- For hepatitis C virus (HCV)-infected patients, diabetes mellitus (DM) is associated with increased risk of hepatocellular carcinoma (HCC) development and all-cause mortality, according to a study published online Dec. 8 in the Journal of Gastroenterology and Hepatology.

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Adjuvant Chemo Plus CRT Best in Nasopharyngeal Carcinoma

MONDAY, Dec. 19, 2016 (HealthDay News) -- For nonmetastatic nasopharyngeal carcinoma, the addition of adjuvant chemotherapy (AC) to chemoradiotherapy (CRT) is associated with the highest survival benefit, according to research published online Dec. 5 in the Journal of Clinical Oncology.

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BRCA1/2, ATM Mutations ID Risk for Lethal Prostate Cancer

FRIDAY, Dec. 16, 2016 (HealthDay News) -- The rate of germline BRCA1/2 and ATM mutations is significantly higher among patients with lethal prostate cancer (PCa) and is an independent predictor of lethal PCa, according to a study published online Dec. 15 in European Urology.

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Imiquimod Has Sustained Benefit for Basal Cell Carcinoma

FRIDAY, Dec. 16, 2016 (HealthDay News) -- For superficial or nodular basal cell carcinoma at low-risk sites, imiquimod has lower treatment success rates than surgery but the benefit is sustained at five years, according to a study published online Dec. 5 in the Journal of Investigative Dermatology.

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CRC in Patients Under 50 Often Caused by Genetic Mutations

FRIDAY, Dec. 16, 2016 (HealthDay News) -- As many as one in six colorectal cancer patients under the age of 50 have genetic traits that greatly increase the risk of cancer, according to a study published online Dec. 15 in JAMA Oncology.

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MRI Has a Role to Play After Negative Prostate Biopsy

THURSDAY, Dec. 15, 2016 (HealthDay News) -- Magnetic resonance imaging (MRI) and MRI-targeted biopsies have a role in the diagnosis and treatment of patients with a prior negative prostate biopsy, according to a review published in the December issue of The Journal of Urology.

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Microsurgical Head and Neck Reconstruction Is Cost-Effective

THURSDAY, Dec. 15, 2016 (HealthDay News) -- For patients with squamous cell carcinoma (SCC), microsurgical head and neck reconstruction is cost-effective compared with locoregional flaps, according to a study published online Nov. 29 in Head & Neck.

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ASS1 Loss Identified in Invasive Bladder Cancer

THURSDAY, Dec. 15, 2016 (HealthDay News) -- Loss of argininosuccinate synthetase 1 (ASS1), a key enzyme for arginine synthesis, occurs in invasive bladder cancer, according to a study published online Dec. 12 in The American Journal of Pathology.

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SIOP Scale Best for Detecting Ototoxicity With Cisplatin Tx

THURSDAY, Dec. 15, 2016 (HealthDay News) -- The Society for Industrial and Organizational Psychology Ototoxicity Scale (SIOP) seems to be best for classifying ototoxicity in cisplatin-treated pediatric patients, according to a study published online Dec. 12 in the Journal of Clinical Oncology.

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Triple-Negative Breast Cancer Subtype Chemosensitive

WEDNESDAY, Dec. 14, 2016 (HealthDay News) -- For patients with triple-negative breast cancer (TNBC), a BRCA-deficiency (BRCA-D) subtype is chemosensitive, according to a study published online Dec. 13 in PLOS Medicine.

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Type of Treatment Impacts Recurrence in Laryngeal SCC

WEDNESDAY, Dec. 14, 2016 (HealthDay News) -- For patients with laryngeal squamous cell carcinoma (SCC), factors predictive of recurrence include neck metastasis at presentation and nonsurgical treatment, according to a study published online Nov. 30 in Head & Neck.

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Cetuximab + Chemoradiation Can Cure HIV-Associated Anal Cancer

WEDNESDAY, Dec. 14, 2016 (HealthDay News) -- Definitive chemoradiation (CRT) can potentially cure HIV-associated squamous cell carcinoma of the anal canal (SCCAC), with the addition of cetuximab resulting in less locoregional failure (LRF), according to a study published online Dec. 12 in the Journal of Clinical Oncology.

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Outcomes-Based Pricing Suggested for New, Costly Drugs

WEDNESDAY, Dec. 14, 2016 (HealthDay News) -- Outcomes-based pricing for novel and expensive biopharmaceuticals is supported in an Ideas and Opinions piece published online Dec. 13 in the Annals of Internal Medicine.

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Atezolizumab Effective in Late-Stage Non-Small-Cell Lung Cancer

TUESDAY, Dec. 13, 2016 (HealthDay News) -- The immunotherapy atezolizumab extends the survival of previously treated non-small-cell lung cancer patients for several months and causes fewer side effects than docetaxel, according to a study published online Dec. 12 in The Lancet.

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OSA Is Risk Factor for Recurrent Pulmonary Embolism

TUESDAY, Dec. 13, 2016 (HealthDay News) -- For patients who stop oral anticoagulation (OAC) for a first episode of pulmonary embolism (PE), obstructive sleep apnea (OSA) is a risk factor for PE recurrence and restarting OAC for a new thromboembolic event, according to a study published in the December issue of CHEST.

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Methylation of PITX2 DNA Feasible in Prostate Biopsies

TUESDAY, Dec. 13, 2016 (HealthDay News) -- For patients with prostate cancer (PCa), methylation of the paired-like homeodomain transcription factor 2 (PITX2) gene is feasible for individualized risk assessment in prostate core biopsies before surgery, according to a study published online Dec. 8 in the Journal of Molecular Diagnostics.

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Social Isolation Can Adversely Affect Breast Cancer Survival

MONDAY, Dec. 12, 2016 (HealthDay News) -- Social isolation may impede long-term breast cancer survival, according to a study published online Dec. 12 in Cancer.

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Drones Deemed Safe for Blood Transportation

MONDAY, Dec. 12, 2016 (HealthDay News) -- Blood products don't seem to suffer damage when transported by drones, according to a study published online Nov. 11 in Transfusion.

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Stepped Care Likely to Be Cost-Effective in Head & Neck, Lung CA

MONDAY, Dec. 12, 2016 (HealthDay News) -- A stepped care (SC) program is likely to be cost-effective for patients with head and neck cancer or lung cancer who have psychological distress, according to a study published online Dec. 5 in the Journal of Clinical Oncology.

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Cytotoxic T-Cells Can Induce Metastatic CRC Regression

FRIDAY, Dec. 9, 2016 (HealthDay News) -- Administration of cytotoxic T-cells targeting mutant KRAS G12D can induce tumor regression in metastatic colorectal cancer, according to a case report published in the Dec. 8 issue of the New England Journal of Medicine.

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Screening Cuts Transfusion-Transmitted Babesiosis Risk

FRIDAY, Dec. 9, 2016 (HealthDay News) -- Screening for Babesia microti antibodies and DNA in blood-donation samples is associated with a reduction in the risk of transfusion-transmitted babesiosis, according to a study published in the Dec. 8 issue of the New England Journal of Medicine.

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Personalized Vaccine Effective Against Acute Myeloid Leukemia

THURSDAY, Dec. 8, 2016 (HealthDay News) -- A vaccine made from patient-derived acute myeloid leukemia cells and dendritic cells can dramatically increase the chance of long-term survival against acute myeloid leukemia, according to research published in the Dec. 7 issue of Science Translational Medicine.

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Prevalence of Disability 2.7 Percent at U.S. Medical Schools

WEDNESDAY, Dec. 7, 2016 (HealthDay News) -- The prevalence of disability is 2.7 percent among medical students at U.S. allopathic medical schools, according to a research letter published in the Dec. 6 issue of the Journal of the American Medical Association, a theme issue of medical education.

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Learning Interventions Can Improve Med Student Well-Being

WEDNESDAY, Dec. 7, 2016 (HealthDay News) -- Specific learning interventions may improve emotional well-being among medical students, according to a review published in the Dec. 6 issue of the Journal of the American Medical Association, a theme issue on medical education.

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Number of Cancer Cases, Deaths Up Globally

WEDNESDAY, Dec. 7, 2016 (HealthDay News) -- Cancer cases rose 33 percent worldwide in the past 10 years, according to a report published online Dec. 3 in JAMA Oncology.

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Depression, Suicide Ideation Prevalent in Medical Students

TUESDAY, Dec. 6, 2016 (HealthDay News) -- The prevalences of depression or depressive symptoms and suicide ideation are 27.2 and 11.1 percent, respectively, among medical students, according to a review published in the Dec. 6 issue of the Journal of the American Medical Association, a theme issue on medical education.

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HPV16 DNA From Fine-Needle Aspirations OK for Diagnosis

TUESDAY, Dec. 6, 2016 (HealthDay News) -- HPV16 DNA detected in fine-needle aspirations from neck masses is a reliable indicator for diagnosis of an HPV-positive oropharyngeal squamous cell carcinoma (SCC), according to a study published Nov. 29 in Head & Neck.

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Biosimilar Promising for ERBB2+ Breast Cancer Treatment

MONDAY, Dec. 5, 2016 (HealthDay News) -- A proposed biosimilar is comparable to trastuzumab for women with ERBB2-positive metastatic breast cancer, according to a study published online Dec. 1 in the Journal of the American Medical Association.

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Multimodal Breast Cancer Tx May Up Cytokines, Comorbidities

MONDAY, Dec. 5, 2016 (HealthDay News) -- Breast cancer survivors who undergo multimodal treatment have higher cytokines and comorbidities than controls without cancer, according to a study published online Nov. 28 in the Journal of Clinical Oncology.

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Review: Methodological Limitations for OSCC Biomarkers

MONDAY, Dec. 5, 2016 (HealthDay News) -- Methodological concerns have limited the analysis of saliva-based biomarkers for oral squamous cell carcinoma (OSCC), according to a review published online Nov. 29 in Head and Neck.

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Acute, Noncardiac Mortality Risk Up for CA Patients With STEMI

FRIDAY, Dec. 2, 2016 (HealthDay News) -- Cancer survivors with ST-segment elevation myocardial infarction (STEMI) have increased acute in-hospital and long-term noncardiac mortality risk but no increased acute or long-term cardiac mortality risk with guideline-recommended cardiac care, according to a study published in the December issue of the Mayo Clinic Proceedings.

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Alcohol Intake Linked to Increase in Risk of Melanoma

FRIDAY, Dec. 2, 2016 (HealthDay News) -- Alcohol intake is associated with increased risk of melanoma, especially in relatively ultraviolet (UV)-spared areas, according to a study published in the December issue of Cancer, Epidemiology, Biomarkers & Prevention.

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Meds Don't Cut Trastuzumab-Tied Left Ventricular Remodeling

FRIDAY, Dec. 2, 2016 (HealthDay News) -- For patients with human epidermal growth factor receptor 2-overexpressing (HER2-positive) early breast cancer, perindopril and bisoprolol do not prevent trastuzumab-mediated left ventricular remodeling, according to a study published online Nov. 28 in the Journal of Clinical Oncology.

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Psilocybin Can Pull Cancer Patients Quickly Out of Despair

THURSDAY, Dec. 1, 2016 (HealthDay News) -- A single dose of psilocybin can quickly lifts the spirits of cancer patients, and the effect can last as long as six months, according to two studies published online Dec. 1 in the Journal of Psychopharmacology.

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AND: Vegetarian Diet a Healthy, Environmentally Sound Choice

THURSDAY, Dec. 1, 2016 (HealthDay News) -- Vegetarian diets are healthy for people of all ages, as well as the environment, according to a new position statement from the Academy of Nutrition and Dietetics (AND). The report has been published in the December issue of the Journal of the Academy of Nutrition and Dietetics.

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Increased VTE Risk for Men Starting Testosterone Therapy

THURSDAY, Dec. 1, 2016 (HealthDay News) -- Starting testosterone treatment is associated with an increased risk of venous thromboembolism (VTE), peaking within six months and declining thereafter, according to a study published online Nov. 30 in The BMJ.

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CDC: Fewer U.S. Families Struggling to Pay Medical Bills

THURSDAY, Dec. 1, 2016 (HealthDay News) -- The number of people in families having problems paying medical bills fell by nearly 13 million from 2011 through the first six months of 2016, according to a report published by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS).

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Study Supports Smoking Cessation for Smokers of Any Age

THURSDAY, Dec. 1, 2016 (HealthDay News) -- Age at smoking initiation and cessation continue to be important predictors of mortality in U.S. adults over age 70, according to a study published online Nov. 29 in the American Journal of Preventive Medicine.

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