Data From Clinical Registries Can ID Novel Drug Interactions

Share this content:
Data From Clinical Registries Can ID Novel Drug Interactions
Data From Clinical Registries Can ID Novel Drug Interactions

THURSDAY, Nov. 17, 2016 (HealthDay News) -- Data mining can be used to discover unknown drug-drug interactions in cardiovascular medicine, according to a study published online Nov. 8 in Circulation: Cardiovascular Quality and Outcomes.

Peter Waede Hansen, M.D., from the Danish Heart Foundation in Copenhagen, and colleagues analyzed altered prothrombin time after initiation of a novel prescription in previously international normalized ratio (INR)-stable warfarin-treated patients with nonvalvular atrial fibrillation. A machine-learning method (random forest) was established to predict altered INR levels after novel prescriptions. The most important drugs from the analysis were further investigated in a new data set. A total of 220 drug groups were analyzed in 61,190 novel prescriptions.

The researchers rediscovered two drug groups with known interactions (β-lactamase-resistant penicillins and carboxamide derivatives) and three antithrombotic/anticoagulant agents that caused a decrease in INR (platelet aggregation inhibitors excluding heparin, direct thrombin inhibitors, and heparins). They also rediscovered six drug groups with known interactions causing increased INR, and two in a closely related drug group that had a known interaction. An unknown signal of increasing INR was seen for antipropulsives.

"We were able to identify known warfarin-drug interactions without a prior hypothesis using clinical registries. Additionally, we discovered a few potentially novel interactions," the authors write. "This opens up for the use of data mining to discover unknown drug-drug interactions in cardiovascular medicine."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »