DAPT Use Variable in Patients With A-Fib at Risk of Stroke

Share this content:
DAPT Use Variable in Patients With A-Fib at Risk of Stroke
DAPT Use Variable in Patients With A-Fib at Risk of Stroke

MONDAY, Aug. 15, 2016 (HealthDay News) -- For patients with atrial fibrillation at moderate to high risk of stroke, dual antiplatelet therapy (DAPT) use is variable among those undergoing percutaneous coronary intervention (PCI), according to a study published in the Aug. 22 issue of JACC: Cardiovascular Interventions.

Matthew W. Sherwood, M.D., from the Duke University School of Medicine in Durham, N.C., and colleagues examined use of DAPT and outcomes in patients undergoing PCI in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation.

The researchers found that during a median of 806 days of follow-up, 1.1 percent of the 14,171 patients underwent PCI. Rivaroxaban-treated patients were significantly less likely to undergo PCI than those treated with warfarin (61 versus 92; P = 0.01). Eighty-one percent of patients continued the study drug during PCI. Long-term DAPT and single antiplatelet therapy were used in 37 and 34 percent, respectively. Within 30 days of PCI, 12.3 percent of patients switched from DAPT to monotherapy; 15 percent of patients received no antiplatelet therapy after PCI. In post-PCI patients, the rates of stroke/systemic embolism and major bleeding events were high in both treatment groups (4.5 and 10.2/100 patient-years, respectively).

"Rates of both thrombotic and bleeding events were high after PCI, highlighting the need for studies to determine the optimal antithrombotic therapy," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Medicare Requiring Hospitals to Post Prices Online

Medicare Requiring Hospitals to Post Prices Online

Medicare would base part of a hospital's payments on how easy it is for patients to access medical records

Restless Brain Syndrome Tied to Changes in the Brain

Restless Brain Syndrome Tied to Changes in the ...

Morphological differences seen in the primary somatosensory system

People With Opioid Use Disorder Have High Suicide Rate

People With Opioid Use Disorder Have High Suicide ...

Based on data from multiple sources, many opioid-overdose deaths seem to be suicides

is free, fast, and customized just for you!

Already a member?

Sign In Now »