CYP2C19-Genotype Guided Antiplatelet Tx May Be Beneficial

Share this content:
<i>CYP2C19</i>-Genotype Guided Antiplatelet Tx May Be Beneficial
CYP2C19-Genotype Guided Antiplatelet Tx May Be Beneficial

FRIDAY, Nov. 3, 2017 (HealthDay News) -- Patients with a CYP2C19 loss-of-function allele have increased risk of major adverse cardiovascular events (MACE) with clopidogrel versus alternative antiplatelet therapy after percutaneous coronary intervention (PCI), according to a study published online Nov. 1 in JACC: Cardiovascular Interventions.

Larisa H. Cavallari, Pharm.D., from the University of Florida in Gainesville, and colleagues examined outcomes following clinical implementation of CYP2C19 genotype-guided antiplatelet therapy after PCI. The authors compared MACE within 12 months of PCI for patients with a loss-of-function allele prescribed clopidogrel versus alternative therapy.

The researchers found that 31.5 percent of the 1,815 patients had a loss-of-function allele. Patients with a loss-of-function allele prescribed clopidogrel had a significantly higher risk for MACE versus those prescribed alternative therapy (23.4 versus 8.7 per 100 patient-years; adjusted hazard ratio, 2.26; 95 percent confidence interval, 1.18 to 4.32; P = 0.013). Among the 1,210 patients with an acute coronary syndrome at the time of PCI, the results were similar (adjusted hazard ratio, 2.87; 95 percent confidence interval, 1.35 to 6.09; P = 0.013). Patients without a loss-of-function allele and loss-of-function allele carriers prescribed alternative therapy had no difference in MACE (adjusted hazard ratio, 1.14; 95 percent confidence interval, 0.69 to 1.88; P = 0.6).

"A future randomized study of genotype-guided antiplatelet therapy may be of value," the authors write.

Two authors disclosed ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

FDA OKs Nucala for Eosinophilic Granulomatosis With Polyangiitis

FDA OKs Nucala for Eosinophilic Granulomatosis With Polyangiitis

First drug to be approved for rare autoimmune disease that leads to vasculitis

Findings Support Individualized Glycemic Control in T2DM

Findings Support Individualized Glycemic Control in T2DM

Approach saved $13,547/patient vs uniform intensive control, with lower medication costs

Atherosclerosis ID'd in Many Without CV Risk Factors

Atherosclerosis ID'd in Many Without CV Risk Factors

LDL-C independently associated with the presence and extent of atherosclerosis

is free, fast, and customized just for you!

Already a member?

Sign In Now »