CT-Gross Tumor Volume Predicts Outcome in Larynx Preservation

This article originally appeared here.
Share this content:
CT-Gross Tumor Volume Predicts Outcome in Larynx Preservation
CT-Gross Tumor Volume Predicts Outcome in Larynx Preservation

THURSDAY, May 5, 2016 (HealthDay News) -- For patients undergoing larynx preservation, pretreatment computed tomography-gross tumor volume (CT-GTV) is predicative of an increase in time with tracheostomy and percutaneous endoscopic gastrostomy (PEG), according to a study published online April 30 in Head & Neck.

Newton J. Hurst Jr., M.D., Ph.D., from Wayne State University in Detroit, and colleagues examined the predictive value of pretreatment GTV for persistence of tracheostomy and PEG tube in larynx preservation patients. Before initiation of therapy, 75 patients underwent CT and the GTV was contoured. GTV information was available for 41 patients.

The researchers found that threshold GTVs of 27.16 cc and 12 cc were identified for association of time with a tracheostomy and PEG tube, respectively, using recursive partitioning analysis. For time with tracheostomy, the median times above and below these thresholds were 1.84 and 0.75 years, respectively (P = 0.03); the corresponding values were 1.75 and 0.84 years for time with PEG tube (P = 0.10).

"We demonstrate here that pretreatment CT-GTV is predictive of an approximately 2.5-fold and approximately 2-fold, respectively, increase in length of time with a tracheostomy and a PEG tube -- two surrogates for poor functional outcomes and reduced quality of life," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Saturday Is National Prescription Drug Take Back Day

Saturday Is National Prescription Drug Take Back Day

Unused medications can be dropped off at local collection sites between 10 a.m. and 2 p.m.

Multiple Myeloma Risk May Be Up for WTC-Exposed Firefighters

Multiple Myeloma Risk May Be Up for WTC-Exposed ...

And, cancer burden projected to be greater than expected for world trade center-exposed firefighters

Pros and Cons for E-Cigarettes As Aid to Smoking Cessation

Pros and Cons for E-Cigarettes As Aid to ...

Researchers present evidence supporting their use, and discuss the limits and hazards of use

is free, fast, and customized just for you!

Already a member?

Sign In Now »