CPX Testing Predicts Mortality in Heart Failure With Reduced EF

Share this content:
CPX Testing Predicts Mortality in Heart Failure With Reduced EF
CPX Testing Predicts Mortality in Heart Failure With Reduced EF

TUESDAY, Feb. 16, 2016 (HealthDay News) -- Variables measured during a cardiopulmonary exercise (CPX) test can predict and discriminate mortality in patients with heart failure with reduced ejection fraction (HFrEF), according to a study published in the Feb. 23 issue of the Journal of the American College of Cardiology.

Steven J. Keteyian, Ph.D., from the Henry Ford Hospital in Detroit, and colleagues report on the strength of the association among variables measured during a CPX test and all-cause mortality in patients with HFrEF. Ten CPX test variables were measured at baseline among 2,100 patients enrolled in the Heart Failure-A Controlled Trial Investigating Outcomes of Exercise Training.

The researchers identified 357 deaths over a median follow-up of 32 months. With the exception of respiratory exchange ratio, all CPX variables correlated with all-cause mortality (P < 0.0001). Percent predicted peak oxygen uptake (ppVo2) and exercise duration were able to predict and discriminate mortality equally (c-index, 0.69). Among men and women, respectively, the strongest predictor of mortality was peak Vo2 and exercise duration. Percent ppVo2, exercise duration, and peak Vo2 were similarly able to predict and discriminate mortality, in multivariable analyses. A 10 percent one-year mortality rate corresponded to peak Vo2 of 10.9 ml/kg−1/min−1 in men versus 5.3 ml/kg−1/min−1 in women.

"Peak Vo2, exercise duration, and percent ppVo2 carried the strongest ability to predict and discriminate the likelihood of death in patients with HFrEF," the authors write. "The prognosis associated with a given peak Vo2 differed by sex."

One author disclosed financial ties to Merck Research Laboratories.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Hormonal Contraception May Raise Depression Risk

Hormonal Contraception May Raise Depression Risk

Study also ties hormonal patches, IUDs to greater antidepressant use, especially in teens

Dose-Dependent Link Between Cannabis Use, Psychosis Relapse

Dose-Dependent Link Between Cannabis Use, Psychosis Relapse

But researchers note effect is small, and the research isn't definitive

Systolic Blood Pressure Variability Linked to Mortality, Morbidity

Systolic Blood Pressure Variability Linked to Mortality, Morbidity

Increased SBP variability tied to mortality, coronary heart disease, stroke, end-stage renal disease

is free, fast, and customized just for you!

Already a member?

Sign In Now »