Contraindication to Antiplatelet Rx for ~18 Percent With PCI

This article originally appeared here.
Share this content:
Contraindication to Antiplatelet Rx for ~18 Percent With PCI
Contraindication to Antiplatelet Rx for ~18 Percent With PCI

FRIDAY, June 3, 2016 (HealthDay News) -- About 18 percent of patients undergoing percutaneous coronary intervention (PCI) have a contraindication to commonly used antiplatelet medications, according to a study published online May 31 in Circulation: Cardiovascular Quality and Outcomes.

Geoffrey D. Barnes, M.D., from the Ann Arbor VA Medical Center in Michigan, and colleagues evaluated patients with contraindications to commonly used antiplatelet medications during and after PCI. The authors used national Veterans Affairs Clinical Assessment, Reporting, and Tracking program data for all PCIs performed between 2007 and 2013. They examined the correlation between contraindicated medications and outcomes of periprocedural bleeding and 30-day mortality.

The researchers found that 17.6 percent of the 64,294 patients undergoing PCI had a contraindication to a common antiplatelet medication, and 6.5 percent of these patients received a contraindicated medication. Any contraindicated medication use correlated with increased bleeding and 30-day mortality in unadjusted-analyses. After adjustment, significant correlations persisted for contraindicated abciximab use in patients with thrombocytopenia (hazard ratio, 2.23) and in patients with a previous stroke (hazard ratio, 1.93). In adjusted models there was no significant correlation noted for contraindicated abciximab use with 30-day mortality. In dialysis patients, eptifibatide use was not associated with an increased risk of bleeding or mortality.

"Approximately 6 percent of those patients received a contraindicated medication with attendant bleeding risk, although this did not translate into significantly higher risk of 30-day mortality," the authors write.

Two authors disclosed financial ties to the pharmaceutical, medical device, and health insurance industries.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

Walmart Launches Disposal Solution for Opioids, Rx Meds

Walmart Launches Disposal Solution for Opioids, Rx Meds

DisposeRx, available at no cost, transforms prescription drugs into non-divertible, biodegradable gel

ADHD Meds Increasingly Prescribed to Reproductive-Aged Women

ADHD Meds Increasingly Prescribed to Reproductive-Aged Women

Increase of 344 percent, from 0.9 percent of women in 2003 to 4 percent of women in 2015

Bikram Yoga Improves Vascular Health With or Without Heat

Bikram Yoga Improves Vascular Health With or Without ...

Increase in brachial artery flow-mediated dilation seen in heated and thermoneutral environment

is free, fast, and customized just for you!

Already a member?

Sign In Now »