Competing Risks Influence Warfarin, Thromboembolism Link

Share this content:
Competing Risks Influence Warfarin, Thromboembolism Link
Competing Risks Influence Warfarin, Thromboembolism Link

THURSDAY, Nov. 17, 2016 (HealthDay News) -- For patients with nonvalvular atrial fibrillation, warfarin is associated with a reduction in thromboembolism, although the correlation is attenuated after accounting for competing death events, according to a study published online Nov. 12 in the Journal of the American Geriatrics Society.

Jeffrey M. Ashburner, Ph.D., M.P.H., from Massachusetts General Hospital in Boston, and colleagues conducted a cohort study involving 13,559 adults with nonvalvular atrial fibrillation between 1996 and 2003. The authors estimated cause-specific hazard ratios for thromboembolism and the competing risk event (all-cause death) with longitudinal warfarin exposure.

The researchers found that the rate of death was much higher in the group not taking warfarin versus those taking warfarin (8.1 versus 5.5 deaths/100 person-years). The cause-specific hazard ratio indicated a large decrease in thromboembolism with warfarin use (adjusted hazard ratio, 0.57); after accounting for competing death events, the correlation was attenuated substantially (adjusted hazard ratio, 0.87). The results for models that did and did not account for competing risks were similar in analyses limited to one year of follow-up.

"Analyses accounting for competing death events may provide a more-realistic estimate of the longer-term stroke prevention benefits of anticoagulants than traditional noncompeting risk analyses for individuals with atrial fibrillation, particularly those who are not currently treated with anticoagulants," the authors write.

Several authors disclosed financial ties to the biopharmaceutical and medical technology industries.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Tai Chi Found to Be Beneficial for Veterans With PTSD

Tai Chi Found to Be Beneficial for Veterans ...

Chinese exercise regimen helps veterans cope with distressing symptoms of PTSD

Healthy Diet May Help Lengthen the Lives of CKD Patients

Healthy Diet May Help Lengthen the Lives of ...

Study found eating lots of fruit, vegetables, fish, whole grains was linked to lower rate of early death

Regular Cannabis Use May Affect Retinal Ganglion Cell Function

Regular Cannabis Use May Affect Retinal Ganglion Cell ...

May disrupt, delay signal transmitted along the visual pathway via the optic nerve

is free, fast, and customized just for you!

Already a member?

Sign In Now »