Comorbidity Factors Identified for Exacerbation-Prone Asthma

Share this content:
Comorbidity Factors Identified for Exacerbation-Prone Asthma
Comorbidity Factors Identified for Exacerbation-Prone Asthma

THURSDAY, Sept. 1, 2016 (HealthDay News) -- Factors that are associated with exacerbation-prone asthma (EPA) have been identified, with blood eosinophils, body mass index, and bronchodilator responsiveness associated with exacerbation frequency, according to a study published online Aug. 24 in the American Journal of Respiratory and Critical Care Medicine.

Loren C. Denlinger, M.D., Ph.D., from the University of Wisconsin in Madison, and colleagues examined the clinical, physiological, inflammatory, and comorbidity factors associated with EPA. Patients were classified by the number of exacerbations in the previous year.

The researchers found that 41 percent of the 709 subjects in the National Heart, Lung, and Blood Institute Severe Asthma Research Program (SARP)-3 cohort had no exacerbations and 24 percent were exacerbation prone in the previous year. In SARP-3, factors normally associated with severity (asthma duration, age, sex, race, and socioeconomic status) were not associated with exacerbation frequency; bronchodilator responsiveness differentiated exacerbation proneness from asthma severity. There were positive associations for blood eosinophils, body mass index, and bronchodilator responsiveness with exacerbation frequency in the SARP-3 multivariable model. Even after adjustment for multiple factors, chronic sinusitis and gastroesophageal reflux were also associated with exacerbation frequency. In the SARP 1 + 2 multivariable model, these effects were replicated.

"EPA may be a distinct susceptibility phenotype with implications for the targeting of exacerbation prevention strategies," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Hormonal Contraception May Raise Depression Risk

Hormonal Contraception May Raise Depression Risk

Study also ties hormonal patches, IUDs to greater antidepressant use, especially in teens

Dose-Dependent Link Between Cannabis Use, Psychosis Relapse

Dose-Dependent Link Between Cannabis Use, Psychosis Relapse

But researchers note effect is small, and the research isn't definitive

Systolic Blood Pressure Variability Linked to Mortality, Morbidity

Systolic Blood Pressure Variability Linked to Mortality, Morbidity

Increased SBP variability tied to mortality, coronary heart disease, stroke, end-stage renal disease

is free, fast, and customized just for you!

Already a member?

Sign In Now »