Cognitive Stress Reduces Levodopa Effect in Parkinson's

Share this content:
Cognitive Stress Reduces Levodopa Effect in Parkinson's
Cognitive Stress Reduces Levodopa Effect in Parkinson's

FRIDAY, Jan. 13, 2017 (HealthDay News) -- Cognitive co-activation is associated with a significantly smaller levodopa effect on resting tremor in Parkinson's disease (PD), according to a study published online Jan. 10 in CNS Neuroscience & Therapeutics.

Heidemarie Zach, M.D., from the Radboud University Medical Center in Nijmegen, Netherlands, and colleagues examined whether cognitive stress modulates the levodopa effect on resting tremor in 69 tremulous PD patients. The authors measured the effect of treatment on tremor intensity and tremor variability in two treatment conditions (OFF versus ON levodopa) and in two behavioral contexts (rest versus cognitive co-activation).

The researchers found that levodopa significant reduced tremor intensity across behavioral contexts, while tremor intensity was increased by cognitive co-activation across treatment conditions. Compared with during rest, during cognitive co-activation, the levodopa effect was significantly smaller. There was an increase in resting tremor variability after levodopa, while a decrease was seen during cognitive co-activation.

"Cognitive stress reduces the levodopa effect on Parkinson's tremor," the authors write. "This effect may be explained by a stress-related depletion of dopamine in the basal ganglia motor circuit, by stress-related involvement of nondopaminergic mechanisms in tremor (e.g., noradrenaline), or both. Targeting these mechanisms may open new windows for treatment."

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

NTproBNP Levels Are Significantly Lower in Blacks

NTproBNP Levels Are Significantly Lower in Blacks

Higher NTproBNP levels linked to increased risk of death; this association did not differ by race

Data May Weigh on Pros/Cons of Expanded Care Optometry

Data May Weigh on Pros/Cons of Expanded Care ...

Majority of residents in Kentucky, Oklahoma, New Mexico live within 30 minutes of ophthalmologist

Gaps Seen Between Hearing Loss, Receipt of Medical Evaluation, Tx

Gaps Seen Between Hearing Loss, Receipt of Medical ...

About 20.6 percent of those with hearing less than excellent/good had visited doctor for hearing issues

is free, fast, and customized just for you!

Already a member?

Sign In Now »