Clopidogrel Plus Aspirin Good for Noncarriers of CYP2C19 Variants

This article originally appeared here.
Share this content:
Clopidogrel Plus Aspirin Good for Noncarriers of <i>CYP2C19</i> Variants
Clopidogrel Plus Aspirin Good for Noncarriers of CYP2C19 Variants

TUESDAY, June 28, 2016 (HealthDay News) -- For patients with minor ischemic stroke or transient ischemic attack, the risk of new stroke is reduced with use of clopidogrel plus aspirin versus aspirin alone among those who are not carriers of the CYP2C19 loss-of-function alleles, according to a study published online June 23 in the Journal of the American Medical Association. The research was published to coincide with the Second Annual Scientific Session of the Chinese Stroke Association and the Tiantan International Stroke Conference, held from June 24 to 26 in Beijing.

Yilong Wang, M.D., Ph.D., from the Capital Medical University in Beijing, and colleagues examined the correlation between CYP2C19 gene variants and clinical outcomes of clopidogrel-treated patients. A total of 2,933 patients with acute minor ischemic stroke or transient ischemic attack were randomized to clopidogrel combined with aspirin or aspirin alone. Participants underwent genotyping for three CYP2C19 major alleles.

The researchers found that 41.2 percent of patients were noncarriers and 58.8 percent were carriers of loss-of-function mutations (CYP2C19*2 and *3). Noncarriers, but not carriers, of the loss-of-function alleles had a reduced rate of new stroke with clopidogrel-aspirin after 90-day follow-up (P = 0.02 for interaction). Similar results were seen for the secondary composite efficacy outcome of new composite vascular events. There was no variation for carriers versus noncarriers in the effect of treatment assignment on bleeding (P = 0.78 for interaction).

"These findings support a role of CYP2C19 genotype in the efficacy of this treatment," the authors write.

One author disclosed financial ties to Sanofi and AstraZeneca.

Abstract
Full Text
More Information

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Dermatography Helps Lessen Appearance of Surgical Scars

Dermatography Helps Lessen Appearance of Surgical Scars

Pigments can restore more natural skin appearance that patients are happy with

Drug-Resistant Bacteria Live in America's Water Systems

Drug-Resistant Bacteria Live in America's Water Systems

Bacteria found in plumbing may sicken thousands each year

Deep Brain Stimulation May Improve TBI Symptoms

Deep Brain Stimulation May Improve TBI Symptoms

Deep brain stimulation appears to boost function and quality of life

is free, fast, and customized just for you!

Already a member?

Sign In Now »