Clinical Upstaging of NSCLC Seen With Each Progressive Week

This article originally appeared here.
Share this content:
Clinical Upstaging of NSCLC Seen With Each Progressive Week
Clinical Upstaging of NSCLC Seen With Each Progressive Week

TUESDAY, May 1, 2018 (HealthDay News) -- For patients with non-small-cell lung cancer (NSCLC), significant upstaging can occur in each successive week from initial staging to surgery, according to a study presented at the annual meeting of the American Association for Thoracic Surgery, held from April 28 to May 1 in San Diego.

Derek Ray Serna-Gallegos, M.D., from the Cedars-Sinai Medical Center in Los Angeles, and colleagues obtained data for 52,406 patients with clinical stage 1 NSCLC undergoing surgical resection. The rates of upstaging were compared for stage 1 tumors based on the time from completed clinical staging to surgery for the first 12 weeks.

The researchers found that 25.4 percent of resections were performed within one week from the completion of clinical staging. By eight and 12 weeks, 78.9 and 91.2 percent of patients had undergone resection, respectively. Upstaging increased significantly with increasing week from completion of clinical staging to resection. For all clinical stage 1 NSCLC, there was a significant increase in upstaging, with 21.7 and 31.5 percent of patients upstaged after one and eight weeks, respectively. By the 12-week time period there was also a significant increase in upstaging (32.6 percent).

"An astonishing number of clinical stage 1 NSCLC patients upstaged to 3A disease at the time of surgery. Interestingly, a higher proportion of both clinical 1A and 1B patients upstaged to 3A versus 2B, suggesting a possible need for more aggressive mediastinal staging, even in early-staged patients," a coauthor said in a statement. "Although current national guidelines recommend surgery within eight weeks from diagnosis, our study demonstrates there is a benefit in doing surgery even within a week to week basis."

Abstract
More Information

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »