Clinical Evidence Synopsis Published for T2DM

Share this content:
Clinical Evidence Synopsis Published for T2DM
Clinical Evidence Synopsis Published for T2DM

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- Adding a sulfonylurea or metformin to insulin is associated with approximately a 1 percent reduction in hemoglobin A1c (HbA1c), and addition of a sulfonylurea (but not metformin) is associated with more hypoglycemic events, according a clinical evidence synopsis published online Oct. 17 in the Journal of the American Medical Association.

Rimke C. Vos, Ph.D., and Guy E.H.M. Rutten, M.D., Ph.D., from University Medical Center Utrecht in the Netherlands, summarized a research review of studies that examined the effect of the addition of oral hypoglycemic agents among patients with type 2 diabetes who do not achieve optimal glycemic control with insulin monotherapy.

The researchers found that adding a sulfonylurea to insulin was correlated with more hypoglycemic events than insulin alone; this was not seen for metformin. There was an approximate 1 percent decrease in HbA1c with the addition of a sulfonylurea or metformin to insulin.

"Future randomized clinical trials could address the effect of adding oral hypoglycemic agents to insulin therapy for the outcomes of diabetes-related morbidity and mortality, all-cause mortality, and quality of life," the authors write.

The authors disclosed ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC Issues Warning on Contaminated Raw Milk

CDC Issues Warning on Contaminated Raw Milk

Case of New Jersey woman becoming ill after drinking raw milk from Udder Milk company

Cerebral Morphometric Changes Discriminate ADHD, Controls

Cerebral Morphometric Changes Discriminate ADHD, Controls

Alterations discern ADHD-I, ADHD-C, with discriminating features located in DMN, insular cortex

Baby Boomers Have Increased Risk of Rx Opioid Overdose Death

Baby Boomers Have Increased Risk of Rx Opioid ...

In addition, those born from 1947 to 1964 and 1979 to 1992 have increased risk of heroin overdose death

is free, fast, and customized just for you!

Already a member?

Sign In Now »