Circulating Extracellular RNAs Linked to Insulin Resistance

Share this content:
Circulating Extracellular RNAs Linked to Insulin Resistance
Circulating Extracellular RNAs Linked to Insulin Resistance

TUESDAY, Feb. 14, 2017 (HealthDay News) -- Circulating extracellular RNAs (ex-RNAs) are associated with insulin resistance (IR), according to a study published online Feb. 9 in Diabetes Care.

Ravi Shah, M.D., from Massachusetts General Hospital in Boston, and colleagues examined the correlation between ex-RNAs and metabolic phenotypes in 2,317 participants without diabetes in the Framingham Heart Study (FHS) Offspring Cohort. The correlation between candidate ex-RNAs and markers of adiposity was measured. Individuals with diabetes were included in sensitivity analyses. Selected ex-RNAs and metabolites were measured in a separate cohort of 90 overweight/obese youth.

The researchers found that across 391 ex-RNAs in FHS, 18 were associated with IR in age-, sex, and body mass index-adjusted models. Independent of metabolites, miR-122 correlated with IR and regional adiposity in adults and IR in children. Metabolic regulatory roles for miR-122, including regulation of IR pathways, was observed on pathway analysis.

"These results provide translational evidence in support of an important role of ex-RNAs as novel circulating factors implicated in IR," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC Issues Warning on Contaminated Raw Milk

CDC Issues Warning on Contaminated Raw Milk

Case of New Jersey woman becoming ill after drinking raw milk from Udder Milk company

Cerebral Morphometric Changes Discriminate ADHD, Controls

Cerebral Morphometric Changes Discriminate ADHD, Controls

Alterations discern ADHD-I, ADHD-C, with discriminating features located in DMN, insular cortex

Baby Boomers Have Increased Risk of Rx Opioid Overdose Death

Baby Boomers Have Increased Risk of Rx Opioid ...

In addition, those born from 1947 to 1964 and 1979 to 1992 have increased risk of heroin overdose death

is free, fast, and customized just for you!

Already a member?

Sign In Now »