Cholesterol Lowering Rx Cuts Recurrence in Breast Cancer

Share this content:
Cholesterol Lowering Rx Cuts Recurrence in Breast Cancer
Cholesterol Lowering Rx Cuts Recurrence in Breast Cancer

TUESDAY, Feb. 14, 2017 (HealthDay News) -- For women with early-stage, hormone receptor-positive invasive breast cancer, initiation of cholesterol-lowering medication (CLM) during endocrine therapy is associated with improved survival and distant recurrence-free intervals, according to research published online Feb. 13 in the Journal of Clinical Oncology.

Signe Borgquist, M.D., Ph.D., from Harvard Medical School in Boston, and colleagues conducted a randomized, phase III trial (BIG 1-98) involving 8,010 postmenopausal women with early-stage, hormone receptor-positive invasive breast cancer from 1998 to 2003. At study entry and every six months, systemic levels of total cholesterol and use of CLM were measured up to 5.5 years. The relationships between initiation of CLM during endocrine therapy and outcome were assessed.

The researchers found that cholesterol levels declined during tamoxifen therapy. Most of the 789 patients who initiated CLM during endocrine therapy were from the letrozole monotherapy arm, followed by the sequential tamoxifen-letrozole, letrozole-tamoxifen, and tamoxifen monotherapy arms (318, 189, 176, and 106 patients, respectively). There were correlations between initiation of CLM during endocrine therapy and improved disease-free survival, breast cancer-free interval, and distant recurrence-free interval (hazard ratios, 0.79, 0.76, and 0.74, respectively).

"Cholesterol-lowering medication during adjuvant endocrine therapy may have a role in preventing breast cancer recurrence in hormone receptor-positive early-stage breast cancer," the authors write. "We recommend that these observational results be addressed in prospective randomized trials."

Several authors disclosed financial ties to the biopharmaceutical industry.

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

NTproBNP Levels Are Significantly Lower in Blacks

NTproBNP Levels Are Significantly Lower in Blacks

Higher NTproBNP levels linked to increased risk of death; this association did not differ by race

Data May Weigh on Pros/Cons of Expanded Care Optometry

Data May Weigh on Pros/Cons of Expanded Care ...

Majority of residents in Kentucky, Oklahoma, New Mexico live within 30 minutes of ophthalmologist

Gaps Seen Between Hearing Loss, Receipt of Medical Evaluation, Tx

Gaps Seen Between Hearing Loss, Receipt of Medical ...

About 20.6 percent of those with hearing less than excellent/good had visited doctor for hearing issues

is free, fast, and customized just for you!

Already a member?

Sign In Now »