Cell-Free Circulating mtDNA Identifies Parkinson's Disease

This article originally appeared here.
Share this content:
Cell-Free Circulating mtDNA Identifies Parkinson's Disease
Cell-Free Circulating mtDNA Identifies Parkinson's Disease

THURSDAY, Dec. 10, 2015 (HealthDay News) -- Cell-free circulating mitochondrial DNA (ccf-mtDNA) from cerebrospinal fluid (CSF) is reduced in patients with Parkinson's disease (PD), according to research published in the December issue of the Annals of Neurology.

Angela Pyle, Ph.D., from the University of Newcastle Upon Tyne in the United Kingdom, and colleagues examined whether ccf-mtDNA was an early indicator of PD pathology. Fifty-six CSF samples from patients with PD were selected with 10 age-matched asymptomatic control CSF samples.

The researchers observed a significant reduction in ccf-mtDNA in PD cases versus controls, when analyzing two mtDNA targets: MTND1 and MTDN4 copy number. In receiver operating characteristic curve analysis, MTND1- and MTND4-calculated ccf-mtDNA strongly predicted PD status (area under curve, 0.81 and 0.84, respectively). There was no significant correlation for ccf-mtDNA with CSF-tau, -phosphorylated tau, and -α-synuclein.

"Given the severity of the reduction in CSF ccf-mtDNA in PD, and supported by both subsequent measurement and remarkably similar data observed in Alzheimer's Disease, we conclude that ccf-mtDNA is a viable biomarker for the early detection of neurodegenerative disease," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Insulin Glargine, Lixisenatide Combo Beneficial in T2DM

Insulin Glargine, Lixisenatide Combo Beneficial in T2DM

Improved achievement of glycemic targets, reduced body weight

European, American Guidelines Lead to Different Recs for Statins

European, American Guidelines Lead to Different Recs for ...

Quantification of CAC score can improve stratification for those at high, low risk for events

Hyperbaric O2 Therapy Effective in Maxillary Osteoradionecrosis

Hyperbaric O<sub>2</sub> Therapy Effective in Maxillary Osteoradionecrosis

Positive clinical outcome with HBOT for 85.7 percent of patients with maxillary bone osteoradionecrosis

is free, fast, and customized just for you!

Already a member?

Sign In Now »