Cediranib Tx in Relapsed Ovarian CA Doesn't Lower Quality of Life

This article originally appeared here.
Share this content:
Cediranib Tx in Relapsed Ovarian CA Doesn't Lower Quality of Life
Cediranib Tx in Relapsed Ovarian CA Doesn't Lower Quality of Life

FRIDAY, March 31, 2017 (HealthDay News) -- Maintenance therapy with cediranib for women with relapsed ovarian cancer is not detrimental to quality of life (QOL), according to a study published online March 24 in Cancer.

Dan P. Stark, M.D., from St James's University Hospital in Leeds, U.K., and colleagues evaluated year-one QOL data among 456 women randomly allocated to receive standard chemotherapy only, chemotherapy with concurrent cediranib, or chemotherapy with cediranib administered concurrently and continued as maintenance as part of the International Collaboration in Ovarian Neoplasm trial for relapsed ovarian cancer.

The researchers found that the rate of questionnaire compliance was similar across the three groups (90 percent at baseline and 76 percent at year one). At one year, the mean global QOL score was lower for the standard chemotherapy group versus the concurrent-maintenance group (P = 0.18). This finding was robust to the effect of missing data, according to sensitivity analyses. Improvement in QOL became statistically significant after adjustments for self-reported diarrhea.

"The maintenance of QOL along with prolonged cancer control suggests that cediranib has a valuable role in the treatment of relapsed ovarian cancer," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including AstraZeneca, which manufactures cediranib and partially funded the study.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

USPSTF Urges BP Screening for Pre-eclampsia During Pregnancy

USPSTF Urges BP Screening for Pre-eclampsia During Pregnancy

Grade B recommendation suggests substantial net benefit for screening for pre-eclampsia

Evidence Suggests Sodium Guidelines Are Misguided

Evidence Suggests Sodium Guidelines Are Misguided

Dietary sodium intake inversely associated with systolic, diastolic blood pressure in long term

Waiting 10 Months for Colonoscopy May Raise CRC Risk

Waiting 10 Months for Colonoscopy May Raise CRC ...

After positive FIT result, colonoscopy at 10 months also tied to more advanced disease

is free, fast, and customized just for you!

Already a member?

Sign In Now »