CA-125 Strategy Cuts Death, Readmission in Heart Failure

Share this content:
CA-125 Strategy Cuts Death, Readmission in Heart Failure
CA-125 Strategy Cuts Death, Readmission in Heart Failure

THURSDAY, Aug. 11, 2016 (HealthDay News) -- For patients discharged with acute heart failure (AHF), antigen carbohydrate 125-guided therapy (CA125-strategy) is associated with a significant reduction in the risk of one-year death or readmission for AHF, according to a study published online Aug. 10 in JACC: Heart Failure.

Julio Núñez, M.D., from the Universitat de Valencia in Spain, and colleagues conducted a multicenter randomized trial involving 380 patients discharged for AHF and high CA125. Patients were randomized to a CA125-strategy (187 patients) or standard of care (SOC; 193 patients), with the aim of CA125-strategy to reduce CA125 to ≤35 U/ml.

The researchers found that patients assigned to the CA125-strategy were more often visited and treated with ambulatory intravenous loop diuretics and statins; oral loop diuretic and aldosterone receptor blocker doses were more frequently modified. CA125 was associated with a significant reduction in the primary end point of one-year composite of death/AHF readmission, as a first event (P = 0.017) or as recurrent events (P = 0.008). A significant reduction in rehospitalizations, but not mortality, was the driver of the effect.

"CA125-strategy was superior to SOC in terms of reducing the risk of the composite of one-year death/AHF-readmission," the authors write. "This effect was mainly driven by significantly reducing the rate of rehospitalizations."

One author disclosed financial ties to Servier and Ferrer.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Warns Against Children Taking Codeine, Tramadol

FDA Warns Against Children Taking Codeine, Tramadol

Agency strengthens warning labels on these medications to address dangers

Trump Administration Offers Grants to Fight Opioid Crisis

Trump Administration Offers Grants to Fight Opioid Crisis

Money to be used to train health professionals, foster prescription drug monitoring programs

NYC to Raise Cigarette Prices to Highest in the United States

NYC to Raise Cigarette Prices to Highest in ...

Price of pack to jump from $10.50 to $13.00

is free, fast, and customized just for you!

Already a member?

Sign In Now »