C-Section, Maternal Health Impact Odds of Pediatric MS

Share this content:
C-Section, Maternal Health Impact Odds of Pediatric MS
C-Section, Maternal Health Impact Odds of Pediatric MS

FRIDAY, March 31, 2017 (HealthDay News) -- Maternal and perinatal factors that influence the risk of pediatric multiple sclerosis (MS) include cesarean delivery and maternal health during pregnancy, according to a study published in the April issue of Pediatrics.

Jennifer S. Graves, M.D., Ph.D., from the University of California, San Francisco, and colleagues conducted a case-control study involving children with MS or clinically isolated syndrome and healthy controls enrolled at 16 clinics. A comprehensive environmental questionnaire was completed by parents, which included capture of pregnancy and perinatal factors. Responses were available for 265 eligible cases and 412 healthy controls.

In the primary multivariable analysis, the researchers found that maternal illness during pregnancy correlated with 2.3-fold increased odds of having MS, and cesarean delivery correlated with a 60 percent reduction in the odds of MS. After adjustment for these factors, there was no correlation for maternal age, body mass index, tobacco smoke exposure, and breastfeeding with MS. In the secondary analysis, having a father who worked in a gardening-related occupation or any use in the household of pesticide-related products correlated with increased odds of having pediatric MS (odds ratios, 2.18 and 1.73, respectively), after adjustment for age, sex, race, ethnicity, and socioeconomic status.

"Cesarean delivery and maternal health during pregnancy may influence risk for pediatric-onset MS," the authors write. "We report a new possible association of pesticide-related environmental exposures with pediatric MS that warrants further investigation and replication."

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Approves Actemra to Treat Giant Cell Arteritis

FDA Approves Actemra to Treat Giant Cell Arteritis

New indication provides the first FDA-approved therapy specific to this type of vasculitis

Trends in Teen Binge Drinking Still Raise Concerns

Trends in Teen Binge Drinking Still Raise Concerns

Even though frequent binge drinking among adolescents has dropped in past 25 years

ATS: First Abx Rx Doesn't Work for 25 of Pneumonia Cases

ATS: First Abx Rx Doesn't Work for ~25% ...

One in four adult patients do not respond to initial prescription of antibiotic treatment

is free, fast, and customized just for you!

Already a member?

Sign In Now »