Burden of Cirrhosis, Acute-on-Chronic Liver Failure Increasing

This article originally appeared here.
Share this content:
Burden of Cirrhosis, Acute-on-Chronic Liver Failure Increasing
Burden of Cirrhosis, Acute-on-Chronic Liver Failure Increasing

THURSDAY, Oct. 6, 2016 (HealthDay News) -- From 2001 to 2011 there was a considerable increase in the burden of cirrhosis and acute-on-chronic liver failure (ACLF), according to research published online Oct. 3 in Hepatology.

Alina M. Allen, M.D., from the Mayo Clinic in Rochester, Minn., and colleagues used data from the National Inpatient Sample database between 2001 and 2011 to determine time trends in the epidemiology, economic burden, and mortality of ACLF.

The researchers found that the number of hospitalizations for cirrhosis increased from 371,000 in 2001 to 659,000 in 2011 in the United States. Among those hospitalizations, the prevalence of ACLF increased from 1.5 to 5 percent. The inpatient costs for cirrhosis and ACLF increased two- and five-fold ($4.8 to $9.8 billion and $320 million to $1.7 billion, respectively). In 2011, the cost per hospitalization was 3.5-fold higher for ACLF than cirrhosis. For ACLF and cirrhosis, the in-hospital fatality rates decreased from 65 to 50 percent and from 10 to 7 percent, respectively. Predictors of death in ACLF included age, male sex, and the number and types of organ failure.

"Cirrhosis and ACLF represent a substantial and increasing health and economic burden in the United States," the authors write. "These data highlight an urgent need for research for pathophysiological mechanisms, effective therapy, as well as for education of health care providers of its importance in the care of patients with cirrhosis."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Better Stem Cell Tx Outcomes for Younger MS Patients

Better Stem Cell Tx Outcomes for Younger MS ...

Results support additional trials of autologous hematopoietic stem cell transplantation

OD Risk Up in Children Whose Mothers Are Prescribed Opioids

OD Risk Up in Children Whose Mothers Are ...

Second study finds opioids stored unsafely in many households with children

AAP Urges Doctors Not to Punish Pregnant Women for Opioid Use

AAP Urges Doctors Not to Punish Pregnant Women ...

Group says better prevention and treatment, not jail time, would stem surge in drug-addicted newborns

is free, fast, and customized just for you!

Already a member?

Sign In Now »