BRCA1/2, ATM Mutations ID Risk for Lethal Prostate Cancer

Share this content:
<i>BRCA1/2</i>, <i>ATM</i> Mutations ID Risk for Lethal Prostate Cancer
BRCA1/2, ATM Mutations ID Risk for Lethal Prostate Cancer

FRIDAY, Dec. 16, 2016 (HealthDay News) -- The rate of germline BRCA1/2 and ATM mutations is significantly higher among patients with lethal prostate cancer (PCa) and is an independent predictor of lethal PCa, according to a study published online Dec. 15 in European Urology.

Rong Na, from Fudan University in Shanghai, and colleagues directly assessed whether germline mutations in BRCA1/2 and ATM distinguish lethal from indolent PCa. Data were included from a retrospective study of 313 patients who died of PCa and 486 with low-risk localized PCa of European, African, and Chinese descent. Germline DNA from all patients was sequenced for these genes.

The researchers found that lethal PCa patients had a significantly higher combined BRCA1/2 and ATM mutation rate compared with localized PCa patients (6.07 versus 1.44 percent; P = 0.0007). Among lethal PCa patients the rate also differed significantly as a function of age at death (P = 0.046) and time to death after diagnosis (P = 0.0006). After adjustment for race and age, prostate-specific antigen, and Gleason score at the time of diagnosis, being a mutation carrier remained an independent predictor of lethal PCa (hazard ratio, 2.13; P = 0.004).

"Mutation status of BRCA1/2 and ATM distinguishes risk for lethal and indolent PCa and is associated with earlier age at death and shorter survival time," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

ACA Has Increased Coverage, Access for Chronically Ill Patients

ACA Has Increased Coverage, Access for Chronically Ill ...

However, nearly one in seven of those with a chronic disease still lack coverage

Diabetes Care Compromised for Hispanics With Limited English

Diabetes Care Compromised for Hispanics With Limited English

Studies find poor doctor-patient communication hampers medication use, proper glucose control

Catheter Safeguards at Hospitals Cut Bloodstream Infection Rates

Catheter Safeguards at Hospitals Cut Bloodstream Infection Rates

Study finds hospitals that adopt new procedures reap sizable improvements, savings

is free, fast, and customized just for you!

Already a member?

Sign In Now »