BRCA May Not Impact Survival in Young-Onset Breast Cancer

This article originally appeared here.
Share this content:
<i>BRCA</i> May Not Impact Survival in Young-Onset Breast Cancer
BRCA May Not Impact Survival in Young-Onset Breast Cancer

FRIDAY, Jan. 12, 2018 (HealthDay News) -- Survival appears to be similar for patients with young-onset breast cancer who carry a BRCA mutation and noncarriers, according to a study published online Jan. 11 in The Lancet Oncology.

Ellen R. Copson, Ph.D., from the University of Southampton in the United Kingdom, and colleagues conducted a prospective cohort study involving female patients recruited from 127 hospitals in the United Kingdom who were aged 40 years or younger at first diagnosis of invasive breast cancer. BRCA1 and BRCA2 mutations were identified with blood DNA collected at recruitment. Clinicopathological data and data relating to treatment and long-term outcomes were collected from routine medical records. A total of 2,733 women were recruited between Jan. 24, 2000, and Jan. 24, 2008.

The researchers found that 12 percent of patients had a pathogenic BRCA mutation. Overall, 96 percent of the 678 deaths were due to breast cancer after a median follow-up of 8.2 years. Overall survival did not differ significantly for BRCA-positive and BRCA-negative patients at any time point in multivariable analysis. Among the 558 patients with triple-negative breast cancer, overall survival was better for BRCA mutation carriers than noncarriers at two years (95 versus 91 percent; hazard ratio, 0.59) but not at five or 10 years.

"Decisions about timing of additional surgery aimed at reducing future second primary-cancer risks should take into account patient prognosis associated with the first malignancy and patient preferences," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

Pharmacist Participation in Stroke Response Cuts DoorNeedle Time

Pharmacist Participation in Stroke Response Cuts Door&#10140;Needle Time

Pharmacist helps reduces DTN time by median 23.5 min; ups percent of patients meeting ≤60 min goal

Risk of Psychotic Experiences Up With Teen Cannabis Use

Risk of Psychotic Experiences Up With Teen Cannabis ...

Risk also increased with early-onset cigarette-only use, but correlation attenuated after adjustment

Reminder, Recall Systems Improve Immunization Uptake

Reminder, Recall Systems Improve Immunization Uptake

Based on high certainty evidence, postcards, text messages, auto-dialer improve receipt of vaccines

is free, fast, and customized just for you!

Already a member?

Sign In Now »