Botox, InterStim Compared in Female Urinary Incontinence

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Botox, InterStim Compared in Female Urinary Incontinence
Botox, InterStim Compared in Female Urinary Incontinence

TUESDAY, Oct. 4, 2016 (HealthDay News) -- For women with refractory urgency urinary incontinence, onabotulinumtoxinA injections may help control leakage better than the implanted nerve stimulation device InterStim, according to a study published in the Oct. 4 issue of the Journal of the American Medical Association.

Cindy Amundsen, M.D., a professor of obstetrics and gynecology at Duke University in Durham, N.C., and colleagues randomly assigned 364 women to either onabotulinumtoxinA injection or InterStim. The women had to have had at least six urgency incontinent episodes over three consecutive days. The participants were followed for six months.

Among women who kept track of their incontinence for at least four months, far more women who received onabotulinumtoxinA reported a 75 to 100 percent reduction in urgency incontinence symptoms compared to those using InterStim, the researchers found. Women given onabotulinumtoxinA had a greater risk of urinary tract infections, compared to women with the implant -- 35 versus 11 percent. Also, more onabotulinumtoxinA patients needed to use a catheter to relieve urinary retention. The most common side effect for women given the implant was the need to remove or reinsert it, which occurred in just 3 percent of the women.

"Among women with refractory urgency urinary incontinence, treatment with onabotulinumtoxinA compared with sacral neuromodulation resulted in a small daily improvement in episodes that although statistically significant is of uncertain clinical importance," the authors write. "In addition, it resulted in a higher risk of urinary tract infections and need for transient self-catheterizations."

Two authors disclosed financial ties to pharmaceutical and medical device companies, including Allergan, the manufacturer of BOTOX Cosmetic.

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