Blood-Brain Barrier Leaks Seen in Patients With Early Alzheimer's

This article originally appeared here.
Share this content:
Blood-Brain Barrier Leaks Seen in Patients With Early Alzheimer's
Blood-Brain Barrier Leaks Seen in Patients With Early Alzheimer's

WEDNESDAY, June 1, 2016 (HealthDay News) -- Patients in the early stages of Alzheimer's disease may have more leakages in the blood-brain barrier (BBB), according to a study published online May 31 in Radiology.

The findings are based on 16 patients who'd been diagnosed with early Alzheimer's disease, and 17 healthy adults the same age. Walter Backes, Ph.D., and colleagues at Maastricht University in the Netherlands, used a magnetic resonance imaging (MRI) technique to detect areas of brain leakage in each study participant.

The investigators found a significantly higher BBB leakage rate in the total gray matter and cortex for Alzheimer's patients. A significantly higher volume fraction of the leaking brain tissue in the gray matter, normal-appearing white matter, deep gray matter, and cortex was also seen in Alzheimer's patients. The more leakage the study participants had in the brain's deep gray matter and cortex, the worse the Mini-Mental State Examination scores.

"The results of this study showed global BBB leakage in patients with early Alzheimer's disease that is associated with cognitive decline," the authors write. "A compromised BBB may be part of a cascade of pathologic events that eventually lead to cognitive decline and dementia." Backes and his colleagues also raise the possibility that MRI scans could help diagnose Alzheimer's early, by detecting leaks.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

MRI Can Be Safe for Patients With Older Pacemakers, ICDs

MRI Can Be Safe for Patients With Older ...

However, strict procedures need to be followed

ASA: Exercise Boosts Cognitive Function After Stroke

ASA: Exercise Boosts Cognitive Function After Stroke

Most effective programs offer exercises aimed at strength, balance, stretching, and aerobic fitness

ASA: Headache Precedes Stroke More Often in Kids Than Adults

ASA: Headache Precedes Stroke More Often in Kids ...

However, ischemic strokes still very rare in children

is free, fast, and customized just for you!

Already a member?

Sign In Now »