Blood-Brain Barrier Leaks Seen in Patients With Early Alzheimer's

This article originally appeared here.
Share this content:
Blood-Brain Barrier Leaks Seen in Patients With Early Alzheimer's
Blood-Brain Barrier Leaks Seen in Patients With Early Alzheimer's

WEDNESDAY, June 1, 2016 (HealthDay News) -- Patients in the early stages of Alzheimer's disease may have more leakages in the blood-brain barrier (BBB), according to a study published online May 31 in Radiology.

The findings are based on 16 patients who'd been diagnosed with early Alzheimer's disease, and 17 healthy adults the same age. Walter Backes, Ph.D., and colleagues at Maastricht University in the Netherlands, used a magnetic resonance imaging (MRI) technique to detect areas of brain leakage in each study participant.

The investigators found a significantly higher BBB leakage rate in the total gray matter and cortex for Alzheimer's patients. A significantly higher volume fraction of the leaking brain tissue in the gray matter, normal-appearing white matter, deep gray matter, and cortex was also seen in Alzheimer's patients. The more leakage the study participants had in the brain's deep gray matter and cortex, the worse the Mini-Mental State Examination scores.

"The results of this study showed global BBB leakage in patients with early Alzheimer's disease that is associated with cognitive decline," the authors write. "A compromised BBB may be part of a cascade of pathologic events that eventually lead to cognitive decline and dementia." Backes and his colleagues also raise the possibility that MRI scans could help diagnose Alzheimer's early, by detecting leaks.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

NAFLD Linked to Smaller Total Cerebral Brain Volume

NAFLD Linked to Smaller Total Cerebral Brain Volume

Significant correlation even after adjustment for all covariates, including age, sex, alcohol consumption

Salivary miRNAs Can ID Duration of Concussion Symptoms

Salivary miRNAs Can ID Duration of Concussion Symptoms

Pediatric patients with prolonged symptoms were accurately identified by levels of five miRNAs

Treatment Trajectories Vary for Children With Depression

Treatment Trajectories Vary for Children With Depression

Most common class got psychotherapy monotherapy, and had lowest incidence of attempted suicide

is free, fast, and customized just for you!

Already a member?

Sign In Now »