Blocking Ceramide Production Might Prevent Type 2 Diabetes

Share this content:
Blocking Ceramide Production Might Prevent Type 2 Diabetes
Blocking Ceramide Production Might Prevent Type 2 Diabetes

FRIDAY, Nov. 4, 2016 (HealthDay News) -- High ceramide levels may increase diabetes risk, while low levels could protect against the disease, according to findings from an experimental study published online Nov. 3 in Cell Metabolism.

Noting that overnutrition, inflammatory cytokines, glucocorticoids, and other stress stimuli enhance the rate of sphingolipid synthesis, Bhagirath Chaurasia, Ph.D., from the Laboratory of Translational Metabolic Health in Melbourne, Australia, and colleagues examined the role of this spillover sphingolipid synthesis pathway in adipose function.

The researchers found that, compared to body mass index-matched individuals without diabetes, subcutaneous adipose tissue of patients with type 2 diabetes had considerably more sphingolipids. In mice, whole-body and adipose tissue-specific inhibition or deletion of the first enzyme in the sphingolipid biosynthesis cascade -- serine palmitoyltransferase -- markedly altered adipose morphology and metabolism, especially in subcutaneous adipose tissue. The decline in adipose sphingolipids correlated with increases in brown and beige/brite adipocyte numbers, mitochondrial activity, and insulin sensitivity. In addition, there were increases in the numbers of anti-inflammatory M2 macrophages in the adipose bed and induction of insulin-sensitizing adipokine secretion.

"By blocking ceramide production, we might be able to prevent the development of type 2 diabetes or other metabolic conditions, at least in some people," Chaurasia said in a statement.

One author disclosed financial ties to Centaurus Therapeutics.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

NTproBNP Levels Are Significantly Lower in Blacks

NTproBNP Levels Are Significantly Lower in Blacks

Higher NTproBNP levels linked to increased risk of death; this association did not differ by race

Data May Weigh on Pros/Cons of Expanded Care Optometry

Data May Weigh on Pros/Cons of Expanded Care ...

Majority of residents in Kentucky, Oklahoma, New Mexico live within 30 minutes of ophthalmologist

Gaps Seen Between Hearing Loss, Receipt of Medical Evaluation, Tx

Gaps Seen Between Hearing Loss, Receipt of Medical ...

About 20.6 percent of those with hearing less than excellent/good had visited doctor for hearing issues

is free, fast, and customized just for you!

Already a member?

Sign In Now »