Blocking Ceramide Production Might Prevent Type 2 Diabetes

Share this content:
Blocking Ceramide Production Might Prevent Type 2 Diabetes
Blocking Ceramide Production Might Prevent Type 2 Diabetes

FRIDAY, Nov. 4, 2016 (HealthDay News) -- High ceramide levels may increase diabetes risk, while low levels could protect against the disease, according to findings from an experimental study published online Nov. 3 in Cell Metabolism.

Noting that overnutrition, inflammatory cytokines, glucocorticoids, and other stress stimuli enhance the rate of sphingolipid synthesis, Bhagirath Chaurasia, Ph.D., from the Laboratory of Translational Metabolic Health in Melbourne, Australia, and colleagues examined the role of this spillover sphingolipid synthesis pathway in adipose function.

The researchers found that, compared to body mass index-matched individuals without diabetes, subcutaneous adipose tissue of patients with type 2 diabetes had considerably more sphingolipids. In mice, whole-body and adipose tissue-specific inhibition or deletion of the first enzyme in the sphingolipid biosynthesis cascade -- serine palmitoyltransferase -- markedly altered adipose morphology and metabolism, especially in subcutaneous adipose tissue. The decline in adipose sphingolipids correlated with increases in brown and beige/brite adipocyte numbers, mitochondrial activity, and insulin sensitivity. In addition, there were increases in the numbers of anti-inflammatory M2 macrophages in the adipose bed and induction of insulin-sensitizing adipokine secretion.

"By blocking ceramide production, we might be able to prevent the development of type 2 diabetes or other metabolic conditions, at least in some people," Chaurasia said in a statement.

One author disclosed financial ties to Centaurus Therapeutics.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Better Stem Cell Tx Outcomes for Younger MS Patients

Better Stem Cell Tx Outcomes for Younger MS ...

Results support additional trials of autologous hematopoietic stem cell transplantation

OD Risk Up in Children Whose Mothers Are Prescribed Opioids

OD Risk Up in Children Whose Mothers Are ...

Second study finds opioids stored unsafely in many households with children

AAP Urges Doctors Not to Punish Pregnant Women for Opioid Use

AAP Urges Doctors Not to Punish Pregnant Women ...

Group says better prevention and treatment, not jail time, would stem surge in drug-addicted newborns

is free, fast, and customized just for you!

Already a member?

Sign In Now »