Biomarker Score May Help Predict Response to Cancer Treatment

Share this content:
Biomarker Score May Help Predict Response to Cancer Treatment
Biomarker Score May Help Predict Response to Cancer Treatment

WEDNESDAY, Aug. 31, 2016 (HealthDay News) -- Fourteen genes have been identified that may help determine whether a cancer treatment could help a patient, according to a study published online Aug. 31 in Nature Communications.

The researchers first determined 14 genes that consistently over-express in a large number of cancers. The study team then created a scoring system (Centromere and kinetochore gene Expression Score [CES]) based on the degree of over-expression. A higher score meant more over-expression in those genes.

For several types of major cancers, the higher the score, the worse the prognosis for patients. But "another finding -- one that is counterintuitive -- is that high expression of these genes is also related to more effective chemotherapy and radiation therapy," said principal investigator Gary Karpen, Ph.D., a senior scientist at the U.S. Department of Energy's Lawrence Berkeley National Laboratory in California. The scores could then lead to predicting patient response to specific cancer treatments, according to the study team.

"Our results demonstrate the prognostic and predictive power of the CES, suggest a role for centromere misregulation in cancer progression, and support the idea that tumors with extremely high chromosomal instability are less tolerant to specific genotoxic therapies," the authors conclude.

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

Walmart Launches Disposal Solution for Opioids, Rx Meds

Walmart Launches Disposal Solution for Opioids, Rx Meds

DisposeRx, available at no cost, transforms prescription drugs into non-divertible, biodegradable gel

ADHD Meds Increasingly Prescribed to Reproductive-Aged Women

ADHD Meds Increasingly Prescribed to Reproductive-Aged Women

Increase of 344 percent, from 0.9 percent of women in 2003 to 4 percent of women in 2015

Bikram Yoga Improves Vascular Health With or Without Heat

Bikram Yoga Improves Vascular Health With or Without ...

Increase in brachial artery flow-mediated dilation seen in heated and thermoneutral environment

is free, fast, and customized just for you!

Already a member?

Sign In Now »