Biomarker ID'd for Pregnancy-Induced Glucose Intolerance

Share this content:
Biomarker ID'd for Pregnancy-Induced Glucose Intolerance
Biomarker ID'd for Pregnancy-Induced Glucose Intolerance

THURSDAY, May 11, 2017 (HealthDay News) -- One measurement of plasma glycated CD59 (pGCD59) in pregnancy can predict glucose intolerance, according to a study published online May 3 in Diabetes Care.

Pamela Ghosh, Ph.D., from Brigham and Women's Hospital in Boston, and colleagues conducted a case-control study of 1,000 plasma samples from women receiving standard prenatal care. Five hundred women had a normal glucose challenge test (GCT) for screening of gestational diabetes mellitus (GDM), and 500 had a failed GCT and had a subsequent oral glucose tolerance test (control subjects and case patients, respectively).

The researchers found that the median pGCD59 value was 8.5-fold higher in case patients and 10-fold higher in GDM patients compared with controls: 0.33, 2.79, and 3.23, respectively (P < 0.001). The area under the receiver operating characteristic curve was 0.92. The prevalence of large for gestational age (LGA) was 4.3 and 13.5 percent in the lowest and highest quartiles of pGCD59, respectively.

"One pGCD59 measurement during weeks 24 to 28 identifies pregnancy-induced glucose intolerance with high sensitivity and specificity and can potentially identify the risk for LGA," the authors write.

Two authors disclosed a financial interest in Mellitus, which is developing diagnostic tools for diabetes.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

Walmart Launches Disposal Solution for Opioids, Rx Meds

Walmart Launches Disposal Solution for Opioids, Rx Meds

DisposeRx, available at no cost, transforms prescription drugs into non-divertible, biodegradable gel

ADHD Meds Increasingly Prescribed to Reproductive-Aged Women

ADHD Meds Increasingly Prescribed to Reproductive-Aged Women

Increase of 344 percent, from 0.9 percent of women in 2003 to 4 percent of women in 2015

Bikram Yoga Improves Vascular Health With or Without Heat

Bikram Yoga Improves Vascular Health With or Without ...

Increase in brachial artery flow-mediated dilation seen in heated and thermoneutral environment

is free, fast, and customized just for you!

Already a member?

Sign In Now »