Bilateral Renal Denervation Normalizes Insulin Sensitivity

Share this content:
Bilateral Renal Denervation Normalizes Insulin Sensitivity
Bilateral Renal Denervation Normalizes Insulin Sensitivity

THURSDAY, Nov. 3, 2016 (HealthDay News) -- In obese canines, bilateral renal denervation (RDN) normalizes hepatic insulin sensitivity (SI) by reducing hepatic gluconeogenic genes, according to a study published recently in Diabetes.

Malini S. Iyer, Ph.D., from the Cedars-Sinai Diabetes and Obesity Research Institute in Los Angeles, and colleagues measured SI using euglycemic hyperinsulinemic clamp before and after six weeks of high-fat diet (HFD), and after either RDN or sham surgery.

The researchers found that insulin resistance was induced in the liver after HFD. This insulin resistance persisted in sham animals, while RDN completely normalized hepatic SI in fat-fed dogs; normalization was via reduction of hepatic gluconeogenic genes, including G6Pase, PEPCK, and FOXO1. Upregulation of the liver-X-receptor via the natriuretic peptide pathway was the main mechanism for down-regulation of hepatic gluconeogenesis.

"In conclusion, bilateral RDN completely normalizes hepatic SI in obese canines," the authors write. "These preclinical data implicate a novel mechanistic role for the renal nerves in the regulation of insulin action specifically at the level of the liver and show that the renal nerves constitute a putative new therapeutic target to counteract insulin resistance."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Medicaid Expansion Ups Preemptive Listing for Kidney Transplant

Medicaid Expansion Ups Preemptive Listing for Kidney Transplant

From pre- to post-expansion period, 59 percent relative increase in Medicaid-covered preemptive listings

BCG Vaccine Tied to Reduced Hyperglycemia in Type 1 Diabetes

BCG Vaccine Tied to Reduced Hyperglycemia in Type ...

Systemic shift in glucose metabolism from oxidative phosphorylation to aerobic glycolysis

Many Physicians Not Prepared for End-of-Life Talks With Patients

Many Physicians Not Prepared for End-of-Life Talks With ...

Additional training, reimbursement may foster these critical conversations, authors say

is free, fast, and customized just for you!




Already a member?

Sign In Now »